Parasitology Research

, Volume 82, Issue 1, pp 82–86 | Cite as

Efficacy of ivermectin and moxidectin injection against larvae of wohlfahrtia magnifica (Diptera: Sarcophagidae) in sheep

  • Robert Farkas
  • Martin J. R. Hall
  • Mihály Daniel
  • Lászlo Börzsönyi
Original Paper


The therapeutic efficacies of ivermectin (Ivomec injection, Merck Sharp & Dohme B.V.) and moxidectin (Cydectin 1% injection, American Cyanamid Company) were evaluated in sheep naturally infested with larvae of Wohlfahrtia magnified. Sheep were randomly allocated to one of the 2 groups, each consisting of 19 animals. Sheep in one group received ivermectin and those in the other, moxidectin by subcutaneous injection at a dose of 0.2 mg/kg body weight. Evaluation was performed at 19, 24, 28, 39, 43, 48, 52, 63, 67, 72, 87, 96, 120, 144 and 168 h after treatment. At 144 and 168 h post-treatment, late third-instar larvae were collected from wounds of four sheep in both groups and from untreated, infested sheep. These larvae were reared in the laboratory to assess adult emergence. Neither ivermectin nor moxidectin was effective as a rapid acting treatment or as a long-term, or even short-term, prophylactic. Despite the treatment, 30–40% of sheep had live larvae at every evaluation. Although larvae disappeared from the wounds of some sheep in both groups after the treatment, the wounds in these animals failed to recover and were reinfested by larvae of W. magnified. On day 7 post-treatment the trial had to be finished because the majority of treated sheep were severely infested by Wohlfahrtia maggots. The average number of infested sheep in the two groups and the number of adults that were produced from larvae collected from treated sheep indicate that ivermectin and moxidectin did not differ significantly in efficacy.


Ivermectin Diazinon Abamectin Moxidectin Myiasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Alexander JP (1985) Ivermectin in fly strike. Vet Rec 116:59PubMedGoogle Scholar
  2. Altman DG (1991) Practical statistics for medical research. Chapman and Hall, LondonGoogle Scholar
  3. Anziani OS, Loreficce C (1993) Prevention of cutaneous myiasis caused by screwworm larvae (Cochliomyia hominivorax) using ivermectin. Vet Med J 40:287–290CrossRefGoogle Scholar
  4. Eagleson JS, Thompson DR, Scott PG, Cramer LG, Barick RA (1993) Field trials to confirm the efficacy of ivermectin jetting fluid for control of blow fly strike in sheep. Vet Parasitol 51:107–112PubMedCrossRefGoogle Scholar
  5. Hadani A, Rabinsky R, Shimshoni A, Vishinsky Y (1971) Myiasis caused by Wohlfahrtia magnifica (Schiner) in sheep on the Golan Heights. Refu Vet 28:25–33Google Scholar
  6. Hadani A, Ben Yaakov B, Rosen S (1989) Myiasis caused by Wohlfahrtia magnifica (Schiner, 1862) in the Arabian camel (Camelus dromedarius) in the Peninsula of Sinai. Rev Med Vet Trop 42:33–38Google Scholar
  7. Ishimbekov ZM, Zhanuzakov NH (1983a) Wohlfahrtia infestation in sheep: epizootiology and pathomorphology. Veterinariya 6:19–20Google Scholar
  8. Ishimbekov ZM, Zhanuzakov NZ (1983b) Wohlfahrtiasis of sheep in Kazakhstan and prophylactic measures against it. In: Zhanuzakov NZ (ed) Parazitozy sel’skokhozyaistvennykh zhivotnykh Kazakhstana i mery ikh preduprezhdeniya (in Russian). Kazakhskii Nauchno-Issledovatel’ skii Veterinarnyi Institut, Alma-Ata, pp 52–61Google Scholar
  9. James PS, Picton J, Riek RF (1980) Insecticidal activity of the avermectins. Vet Rec 106:59PubMedGoogle Scholar
  10. Kostov R, Vitanov I, Denev I, Reikov R (1986) Comparative study of therapeutic effects of some preparations against myiasis in sheep. Vet Sbirka 84:26–28Google Scholar
  11. Lehrer Z, Lehrer M, Verstraeten C (1988) Les myiases causées aux moutons de Roumanie par Wohlfahrtia magnifica (Schiner) (Diptera: Sarcophagidae). Ann Med Vet 132:475–81Google Scholar
  12. Lonneux JF, Losson BJ (1992) Field efficacy of injectable and pour-on moxidectin in cattle naturally infested with Psoroptes ovis (Acarina: Psoroptidae). Vet Parasitai 50:147–152CrossRefGoogle Scholar
  13. Lonneux JF, Losson BJ (1994) The efficacy of moxidectin 0,5% pour-on against Hypoderma bovis in naturally infested cattle: parasitological and serological data. Vet Parasitai 52:313–320CrossRefGoogle Scholar
  14. Losson BJ, Lonneux JF (1993) Field efficacy of moxidectin injectable in cattle naturally infested with Chorioptes bovis and Sarcoptes scabiei. Vet Parasitai 51:113–121CrossRefGoogle Scholar
  15. Orton CJ, Watts JE, Rugg D (1992) Comparative effectiveness of avermectins and deltamethrin in suppressing oviposition in Lucilia cuprina (Diptera: Calliphoridae). J Econ Entomol 85:28–32PubMedGoogle Scholar
  16. Perkins ID (1987) Use of insecticides to control screw-worm fly strike by Chrysomya bezziana in cattle. Aust Vet J 64:17–20PubMedCrossRefGoogle Scholar
  17. Roncalli RA, Benitez-Usher C (1988) Efficacy of ivermectin against Dermatobia hominis in cattle. Vet Parasitai 28:343–346CrossRefGoogle Scholar
  18. Ruiz-Martinez I, Soler-Cruz MD, Benitez-Rodriguez R, DiazLopez M, Munoz-Parra S, Florido-Navio A (1987) Myiasis caused by Wohlfahrtia magnifica in southern Spain. Isr J Vet Med 43:34–41Google Scholar
  19. Ruiz-Martinez I, Soler-Cruz MD, Benitez-Rodriguez R, Perez-Jiminez JM, Diaz-Lopez M (1989) Postembryonic development of Wohlfahrtia magnifica (Schiner, 1862) (Diptera: Sarcophagidae). J Parasitai 75:531–539CrossRefGoogle Scholar
  20. Ruiz-Martinez I, Soler-Cruz MD, Benitez-Rodriguez R, Perez-Jimenez JM, Diaz-Lopez M (1991) Myiasis caused by Wohlfahrtia magnifica in sheep and goats in southern Spain. II. Effect of age, body region and sex on larval infestation. Isr J Vet Med 46:64–68Google Scholar
  21. Sachs L (1992) Angewandte Statistik, 7th edn. Springer, Berlin HeidelbergGoogle Scholar
  22. Scholl PJ, Guillot FS, Wang GT (1992) Moxidectin: systemic activity against common cattle grub (Hypoderma lineatum) (Diptera: Oestridae) and trichostrongyle nematodes in cattle. Vet Parasitol 50:203–209CrossRefGoogle Scholar
  23. Spradbery JP, Tozer RS, Drewett N, Lindsey MJ (1985) The efficacy of ivermectin against larvae of the screw-worm fly (Chrysomya bezziana). Aust Vet J 62:311–314PubMedCrossRefGoogle Scholar
  24. Thompson DR, Rugg D, Scott PG, Cramer LG, Barrick RA (1994) Efficacy of ivermectin jetting fluid for the curative treatment of blowfly strikes in sheep. Aust Vet J 71:42–43PubMedCrossRefGoogle Scholar
  25. Titchener RN, Parry JM, Grimshaw TR (1994) Efficacy of formulations of abamectin, ivermectin and moxidectin against sucking and biting lice of cattle. Vet Rec 134:452–453PubMedGoogle Scholar
  26. Zumpf F (1965) Myiasis in man and animals in the Old World: a textbook for physicians, veterinarians and zoologists. Butter-worths, LondonGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Robert Farkas
    • 1
  • Martin J. R. Hall
    • 2
  • Mihály Daniel
    • 1
  • Lászlo Börzsönyi
    • 1
  1. 1.University of Veterinary ScienceBudapest, Pf. 2Hungary
  2. 2.The Natural History MuseumLondonUK

Personalised recommendations