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Clinical features and haematological parameters among malaria patients in Mangaluru city area in the southwestern coastal region of India

  • Kishore Punnath
  • Kiran K. Dayanand
  • Valleesha N. Chandrashekar
  • Rajeshwara N. AchurEmail author
  • Srinivas B. Kakkilaya
  • Susanta K. Ghosh
  • Benudhar Mukhi
  • Vishal Midya
  • Suchetha N. Kumari
  • D. Channe GowdaEmail author
Protozoology - Original Paper
  • 51 Downloads

Abstract

The aim of this study was to assess the clinical profile, severity and complications of patients suffering from malaria in Mangaluru, a southwestern coastal city in India. A total of 579 patients, who were treated at the District Wenlock Hospital, Mangaluru, and 168 healthy controls were recruited in this study. The clinical profile, haematological and biochemical parameters, and disease complications were assessed. The majority of patients were treated as outpatients and patients who had severe clinical conditions were admitted to the hospital for treatment and supportive care. Among the total 579 patients recruited in this study, the distribution of P. vivax, P. falciparum and mixed infections were 364 (62.9%), 150 (25.9%) and 65 (11.2%), respectively. Among these, 506 (87.4%) had mild malaria, whereas 73 (12.6%) had severe malaria. Overall, the clinical features and severity of malaria in P. vivax and mixed infection patients were comparable to P. falciparum patients, albeit with some significant differences. The clinical complications in severe malaria cases included thrombocytopenia (50.7%), metabolic acidosis (30.1%), severe anaemia (26.0%), jaundice (21.9%), hepatic dysfunction (15.1%), acute renal failure (6.8%), haematuria (8.2%), hypotension (9.6%), cerebral malaria (1.4%) and acute respiratory distress syndrome (1.4%). All the patients with severe malaria recruited in our study were successfully treated and discharged. Majority of patients had mild malaria, likely due to seeking treatment soon after experiencing symptoms and/or having preexisting immune protection. However, a significant number of patients had severe malaria and required hospital admission indicating that there is a substantial need for creating awareness among vulnerable immigrant population. Implementing effective surveillance and vector control measures in malaria hotspot locations in the city and educating people about preventive measures are likely to reduce the malaria burden in this endemic region.

Keywords

Mangaluru P. vivax P. falciparum Malaria Clinical features Haematological parameters Hepatic dysfunction 

Abbreviations

NVBDCP

National Vector Borne Disease Control Program

MM

mild malaria

SM

severe malaria

WBCs

white blood cells

RBCs

red blood cells

Hb

haemoglobin

HCT

haematocrit

MPV

mean platelet volume

PDW

platelet distribution width

AST

aspartate transaminase

ALT

alanine transaminase

CM

cerebral malaria

ARDS

acute respiratory distress syndrome

SBP

systolic blood pressure

SMS

short message service

Notes

Acknowledgements

The authors thank the study participants for their consent to participate in the study. We thank Dr. Rajeshwari Devi, District medical officer and superintendent of District Wenlock Hospital for her support and guidance, Dr. Arun Kumar, District Vector Borne Disease Control Programme officer, Dakshina Kannada, for his support and the Mangalore City Corporation Health officials for their kind help to conduct the study.

Funding information

This work was supported by the Grant D43 TW008268 from the Fogarty International Center of the National Institutes of Health, USA, under the Global Infectious Diseases Program. The funders had no role in study design, data collection, and analysis, decision to publish or preparing the manuscript.

Compliance with ethical standards

Ethical approval and consent to participate

The ethics committee of Kuvempu University, Shivamogga, Karnataka, India; the central ethics committee of NITTE University, Mangaluru and the Institutional Review Board of the Pennsylvania State University College of Medicine, Hershey, USA, PA, have approved this study. Informed written consent was obtained from all the study participants

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

436_2019_6540_MOESM1_ESM.xlsx (25 kb)
ESM 1 (XLSX 25 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Kishore Punnath
    • 1
    • 2
  • Kiran K. Dayanand
    • 1
    • 2
  • Valleesha N. Chandrashekar
    • 1
    • 2
  • Rajeshwara N. Achur
    • 2
    Email author
  • Srinivas B. Kakkilaya
    • 3
  • Susanta K. Ghosh
    • 4
  • Benudhar Mukhi
    • 4
  • Vishal Midya
    • 5
  • Suchetha N. Kumari
    • 1
  • D. Channe Gowda
    • 6
    Email author
  1. 1.Department of Biochemistry, K.S. Hegde Medical AcademyNITTE (Deemed to be University)MangaluruIndia
  2. 2.Department of BiochemistryKuvempu UniversityShivamogga DistrictIndia
  3. 3.Light House PolyclinicLight House Hill RoadMangaluruIndia
  4. 4.Department of Molecular ParasitologyICMR-National Institute of Malaria ResearchBangaloreIndia
  5. 5.Department of Biostatistics and BioinformaticsThe Pennsylvania State University College of MedicineHersheyUSA
  6. 6.Department of Biochemistry and Molecular BiologyThe Pennsylvania State University College of MedicineHersheyUSA

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