Parasitology Research

, Volume 118, Issue 1, pp 1–27 | Cite as

Plasmodium genomics: an approach for learning about and ending human malaria

  • José Antonio Garrido-CardenasEmail author
  • Lilia González-Cerón
  • Francisco Manzano-Agugliaro
  • Concepción Mesa-Valle
Genetics, Evolution, and Phylogeny - Review


Malaria causes high levels of morbidity and mortality in human beings worldwide. According to the World Health Organization (WHO), about half a million people die of this disease each year. Malaria is caused by six species of parasites belonging to the Plasmodium genus: P. falciparum, P. knowlesi, P. vivax, P. malariae, P. ovale curtisi, and P. ovale wallikeri. Currently, malaria is being kept under control with varying levels of elimination success in different countries. The development of new molecular tools as well as the use of next-generation sequencing (NGS) technologies and novel bioinformatic approaches has improved our knowledge of malarial epidemiology, diagnosis, treatment, vaccine development, and surveillance strategies. In this work, the genetics and genomics of human malarias have been analyzed. Since the first P. falciparum genome was sequenced in 2002, various population-level genetic and genomic surveys, together with transcriptomic and proteomic studies, have shown the importance of molecular approaches in supporting malaria elimination.


Malaria Plasmodium falciparum P. vivax Vaccine 


Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biology and GeologyUniversity of AlmeriaAlmeriaSpain
  2. 2.Regional Center for Public Health ResearchNational Institute of Public HealthTapachulaMexico
  3. 3.Department of EngineeringUniversity of AlmeriaAlmeriaSpain

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