Parasitology Research

, Volume 117, Issue 8, pp 2437–2443 | Cite as

The course of experimental giardiasis in Mongolian gerbil

  • Radka PeckováEmail author
  • Bohumil Sak
  • Dana Květoňová
  • Martin Kváč
  • Eva Koriťáková
  • Ivona Foitová
Original Paper


Fifteen Mongolian gerbils were inoculated with 10 × 106 viable trophozoites of Giardia intestinalis. Their faeces were examined daily by flotation method and the number of shed cysts was counted. Two animals (male and female) were euthanised at 4- to 5-day intervals (9, 14, 18 days post-infection (DPI)). The remaining nine gerbils were sacrificed and dissected at the end of the experiment (23 DPI). Their small intestinal tissues were processed for examination using histological sectioning and scanning electron microscopy and their complete blood count (CBC) was examined. The highest number of trophozoites at the total was observed in the duodenum in gerbils sacrificed on 14 DPI. Number of shed cysts was positively correlated with number of trophozoites rinsed from the intestine. Infected gerbils had lower body weight gain in comparison with control group and in three male gerbils; diarrhoea occurred during infection. Cyst shedding was negatively correlated with values of mean corpuscular haemoglobin concentration. Females showed another pattern in cyst shedding than males. This information needs to be taken into account while planning the experiments.


Giardial intestinal distribution Giardia intestinalis Giardiasis Gerbil model 



This work was financially supported by the Czech Academy of Sciences, Grant No. P505/11/1163 and Scholarship program to support creative activity-research collaboration, No. PřF_04_27.10.2006.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Radka Pecková
    • 1
    Email author
  • Bohumil Sak
    • 2
  • Dana Květoňová
    • 2
  • Martin Kváč
    • 2
  • Eva Koriťáková
    • 3
  • Ivona Foitová
    • 1
  1. 1.Department of Botany and Zoology, Faculty of ScienceMasaryk UniversityBrnoCzech Republic
  2. 2.Institute of ParasitologyBiology Centre of the Czech Academy of SciencesČeské BudějoviceCzech Republic
  3. 3.Institute of Biostatistics and Analyses, Faculty of MedicineMasaryk UniversityBrnoCzech Republic

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