Laboratory Evaluation of the Efficacy of 10 % Imidacloprid + 2.5 % Moxidectin Topical Solution (Advantage® Multi, Advocate®) for the Treatment of Dirofilaria immitis Circulating Microfilariae in Dogs
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This study aimed to evaluate the efficacy of an emodepside 2.1 % (w/v)/praziquantel 8.6 % (w/v) topical solution (Profender® spot-on for cats) in the prevention of lactogenic Toxocara cati infections. A controlled test was performed with two groups of 8 cats with confirmed pregnancy. All cats were infected with daily doses of 2000 T. cati eggs for 10 consecutive days starting 50 days post conception to produce an acute infection. Treatment was performed 60 days post conception. Queens in the treatment group received the emodepside/praziquantel solution at the minimum therapeutic dose (3 mg/kg emodepside and 12 mg/kg praziquantel), while the control group was treated with a placebo spot-on. Efficacy was evaluated 56 days post partum by necropsy of one randomly selected kitten of each litter and comparison of the worm burdens between the study groups. Additionally the necropsy results were supported by quantification of worms expelled with the faeces after deworming of the remaining kittens and all queens. The treatment in late pregnancy resulted in an efficacy of 98.7 % (p < 0.0001). All necropsied control kittens were infected (geometric mean 30.6). Seven of 8 kittens from treated mothers were free of T. cati (geometric mean 0.4). Worm counts after deworming reflected the results obtained at necropsy. No side effects of the treatment were observed. It is concluded that treatment with an emodepside/praziquantel spot-on solution during late pregnancy effectively prevents lactogenic transmission of T. cati to the offspring. The study design facilitated the generation of reliable data, while at the same time a minimum number of animals was sacrificed.
KeywordsImidacloprid Macrocyclic Lactone Moxidectin Emodepside Heartworm Disease
- American Heartworm Society 2014 Current canine guidelines for the diagnosis, prevention and management of heartworm (Dirofilaria immitis) infections in dogs. Available at http://www.heartwormsociety.org/veterinary-resources/canineguidelines.html#7
- Bowman DD (2009) Diagnostic Parasitology. In: Georgis’ Parasitology for Veterinarians, 9th Edition. Elsevier, St. Louis, pp 318Google Scholar
- Cruthers LR, Arther RG, Basel CL, Charles SD, Hostetler JA, Settje TL (2008) New developments in parasite prevention. Bayer selected proceedings. NAVC 2008 Suppl Vet Forum 25(3B):15–20Google Scholar
- Hellmann K, Heine J, Braun G, Paran-Dobesova R, Svobodava V (2011) Evaluation of the therapeutic and preventive efficacy of 2.5 % moxidectin/10 % imidacloprid (Advocate®. Bayer Animal Health) in dogs naturally infected or at risk of natural infection by Dirofilaria repens Parasitology Res 109(suppl1):77–86Google Scholar
- Hendrix CM, Blagburn BL, Bowles JV, Spano JS, Aguilar R (1992) The safety of moxidectin in dogs with microfilariae and adults of Dirofilaria immitis. In: Soll, MD (ed) Proceedings the American Heartworm Symposium Austin TX: pp 183 – 187Google Scholar
- Louisiana State University School of Veterinary Medicine, Heartworm disease. 2015 available at: http://www1.vetmed.lsu.edu/VTHC/Shared%20Services/Shared%20 Services/…/item41535.html
- Prichard R, Roulet A (2005) Moxidectin Pharmacodynamics: Impact on resistance mechanisms to macrocyclic lactones in laboratory and field strains of nematode parasites. In: Moxidectin: Continued innovation in parasite control 20th WAAVP: pp 19 – 26Google Scholar
- Traversa D, Aste G, Di Cesare A, Paoletti B, Di Tommaso M, Di Giulio E, Pampurini F, Tunesi C, Boari A (2011) Efficacy of a single administration of a spot-on solution containing imidacloprid 10 %/moxidectin 2.5 % in eliminating Dirofilaria repens microfilariae in naturally infected dogsGoogle Scholar
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