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Parasitology Research

, Volume 113, Issue 7, pp 2407–2414 | Cite as

Relevance of free-living amoebae as hosts for phylogenetically diverse microorganisms

  • Patrick Scheid
Review

Abstract

In addition to their role as parasites, free-living amoebae (FLA) can act as hosts of and vehicles for phylogentically diverse microorganisms while some of them replicate intracellularly. These microorganisms are adapted to the intracellular conditions in the amoeba, find suitable conditions and protection from negative environmental influences and take advantage of the dispersal in the environment by their amoebic host. It is expedient to call these organisms “endocytobionts”, at least during the initial steps of any studies. By doing so, it is not necessary to go into potential characteristics of these relationships such as parasitism, phoresy, zoochory, or mutualism at an early stage of study. Among those organisms resisting the lysis within their amoebic host, there are obligate and facultative pathogenic microorganisms affecting the health of humans or animals. FLA-endocytobiont relationships are not only important for the tenacity of the involved microorganisms. Especially if FLA are present in biofilms and there are close ties with many other microorganisms, the odds are for some of these microorganisms to develop human pathogenic properties. Here, the amoebic passage seems to be a prerequisite for the development of virulence factors and it may have an impact on evolutionary processes.

Keywords

Endocytobionts Vectors Virulence development Trojan horses Free-living amoeba Hosts 

Notes

Acknowledgments

The author would like to thank Dr. David Lam (MD, MPH, Shaman Medical Consulting) for review and English-language editing of the article.

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Central Institute of the Bundeswehr Medical Service KoblenzKoblenzGermany

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