Parasitology Research

, Volume 112, Issue 4, pp 1367–1378 | Cite as

Fight against dengue in India: progresses and challenges

  • Bhavna GuptaEmail author
  • B. P. Niranjan Reddy


At the end of the last century, India has faced resurgence of many infectious diseases, of which dengue is one of the most important in terms of morbidity and mortality. The National Vector Borne Disease Control Program data show that dengue is established in India and is becoming endemic to many areas (dengue cases have increased steadily from ∼450 to ∼50,000 from 2000 to 2012). Despite extensive efforts being made in developing the effective dengue control measures, the number of dengue cases, their severity, and geographical boundaries are expanding alarmingly and posing dengue as one of the deadly disease. Recently, the increasing burden of dengue in the country has attracted the scientific as well as Indian Government’s administrative attention; however, a lot remain to be achieved for managing the disease under threshold level. Like other vector-borne diseases, better management of the dengue needs balanced approach involving various aspects like disease prevention, cure/treatment, and the vector control, simultaneously. We have briefly discussed here the situation of dengue in India and have tried to highlight the worrying facets of dengue control and its implementation in Indian perspective. The review on various aspects of dengue control has revealed an urgent need for permanent surveillance programs, coupled with improvised disease diagnostics, effective anti-dengue treatment measures, and controlling the disease transmission by following an effective implementation of vector control programs.


Dengue Virus Dengue Hemorrhagic Fever Dengue Infection Dengue Case Dengue Shock Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This manuscript is dedicated to Megha Bhasme (BG's friend) who died due to dengue in 2011. BG and BPNR thank Drs. Aparup Das, K. Raghavendra, and Prof. G.B.K.S. Prasad for their continuous support and encouragement for writing this review. We also want to thank anonymous reviewer for his valuable comments to improve the manuscript.


  1. Abhyankar AV et al (2006) Comparison of a dipstick dot-ELISA with commercial assays for anti-dengue virus IgM antibodies. Viral Immunol 19:630–636PubMedCrossRefGoogle Scholar
  2. Acharya A, Goswami K, Srinath S, Goswami A (2005) Awareness about dengue syndrome and related preventive practices amongst residents of an urban resettlement colony of south Delhi. J Vector Borne Dis 42(3):122–127PubMedGoogle Scholar
  3. Addlakha R (2001) State legitimacy and social suffering in a modern epidemic: a case study of dengue haemorrhagic fever in Delhi. Contrib Indian Sociol 35(2):151–179CrossRefGoogle Scholar
  4. Aggarwal A, Chandra J, Aneja S, Patwari AK, Dutta AK (1998) An epidemic of dengue hemorrhagic fever and dengue shock syndrome in children in Delhi. Indian Pediatr 35:727–732PubMedGoogle Scholar
  5. Alert GO (2004) WHO/WPRO/SEARO Meeting on DengueNet implementation in South-East Asia and the Western Pacific, Kuala Lumpur, 11–13 December 2003. Dengue Bull 28:227Google Scholar
  6. Arunachalam N et al (2004) Studies on dengue in rural areas of Kurnool District, Andhra Pradesh, India. J Am Mosq Control Assoc 20(1):87–90PubMedGoogle Scholar
  7. Balaya S, Paul SD, D’Lima LV, Pavri KM (1969) Investigations on an outbreak of dengue in Delhi in 1967. Indian J Med Res 57:767–774PubMedGoogle Scholar
  8. Beatty ME et al (2010) Best practices in dengue surveillance: a report from the Asia-Pacific and Americas Dengue Prevention Boards. PLoS Neg Trop Dis 4(11):e890CrossRefGoogle Scholar
  9. Bharati K, Vrati S (2012) Viral vaccines in India: an overview. Proc Natl Acad Sci India Sect B (Biol Sci) 82(1):181–198CrossRefGoogle Scholar
  10. Bhatnagar PK, Katiyar CK, Khanna N, Upadhyay DJ, Swaminathan S, Srinivas K, Sharma N, Kanaujia A, Sood R, Singhal S, Shukla G, Duggar R, Pareek PK, Singh Y, Khan S, Raut R (2009) Anti dengue activity of Cissampelos pariera extracts (International Patent Application Serial No. PCT/IB2010/050299;WO 2010/084477A1)Google Scholar
  11. Bhattacharjee A, Bhattacharjee D (2011) A Bayesian approach to compare the statewise dengue death counts in India. Int J Collab Res Intern Med Public Health 3(10):715–723Google Scholar
  12. Bohra A, Andrianasolo H (2001) Application of GIS in modeling of dengue risk based on sociocultural data: case of Jalore, Rajasthan, India. Dengue Bull 25:92–102Google Scholar
  13. Broor S et al (1997) Recent dengue epidemic in Delhi, India. In: Saluzzo JE, Dodet BP (eds) Factors in the emergence of arbovirus diseases. Elsevier, Paris, pp 123–127Google Scholar
  14. Carey DE, Myers RM, Reuben R, Rodrigues FM (1966) Studies on dengue in Vellore, South India. Bull WHO 35(1):61PubMedGoogle Scholar
  15. Chakravarti A, Gur R, Berry N, Mathur MD (2000) Evaluation of three commercially available kits for serological diagnosis of dengue haemorrhagic fever. Diagn Microbiol Infect Dis 36(4):273–274PubMedCrossRefGoogle Scholar
  16. Chakravarti A, Kumar A, Malik S (2011) Detection of dengue infection by combining the use of an NS1 antigen based assay with antibody detection. Southeast Asian J Trop Med Public Health 42(2):297–302PubMedGoogle Scholar
  17. Chakravarti A, Arora R, Luxemburger C (2012) Fifty years of dengue in India. Trans R Soc Trop Med Hyg 106(5):273–282PubMedCrossRefGoogle Scholar
  18. Chatterjee SN, Chakravarti SK, Mitra AC, Sarkar JK (1965) Virological investigation of cases with neurological complications during the outbreak of haemorrhagic fever in Calcutta. J Indian Med Assoc 45:314–316PubMedGoogle Scholar
  19. Chaturvedi UC, Nagar R (2008) Dengue and dengue haemorrhagic fever: Indian perspective. J Biosci (Bangalore) 33:429–441CrossRefGoogle Scholar
  20. Chaturvedi UC, Shrivastava R (2004) Dengue haemorrhagic fever: a global challenge. Indian J Med Micrbiol 22(1):5–6Google Scholar
  21. Chaturvedi UC, Kapoor AK, Mathur A, Chandra D, Khan AM, Mehrotra RM (1970a) A clinical and epidemiological study of an epidemic of febrile illness with haemorrhagic manifestations which occurred at Kanpur, India, in 1968. Bull WHO 43:281–287PubMedGoogle Scholar
  22. Chaturvedi UC, Mathur A, Kapoor AK, Mehrotra NK, Mehrotra RM (1970b) Virological study of an epidemic of febrile illness with haemorrhagic manifestations at Kanpur, India, during 1968. Bull WHO 43:289–293PubMedGoogle Scholar
  23. Chaudhary R et al (2006) Transfusion support to dengue patients in a hospital based blood transfusion service in north India. Transfus Apher Sci 35(3):239–244PubMedCrossRefGoogle Scholar
  24. Currie D (2012) Globe in brief. Nation’s Health 42(9):19Google Scholar
  25. Dar L, Broor S, Sengupta S, Xess I, Seth P (1999) The first major outbreak of dengue hemorrhagic fever in Delhi, India. Emerg Infect Dis 5(4):589–590PubMedCrossRefGoogle Scholar
  26. Dar L, Gupta E, Narang P, Broor S (2006) Cocirculation of dengue serotypes, Delhi, India, 2003. Emerg Infect Dis 12(2):352–353PubMedCrossRefGoogle Scholar
  27. Dash AP, Chhotray GP, Mahapatra N, Hazra RK (2001) Retrospective analysis of epidemiological investigation of Japanese encephalitis outbreak occurred in Rourkela, Orissa, India. Southeast Asian J Trop Med Public Health 32:137–139PubMedGoogle Scholar
  28. Dash PK et al (2004) Emergence and continued circulation of dengue-2 (genotype IV) virus strains in northern India. J Med Virol 74(2):314–322PubMedCrossRefGoogle Scholar
  29. Dash PK, Saxena P, Abhyankar A, Bhargava R, Jana AM (2005) Emergence of dengue virus type-3 in northern India. Southeast Asian J Trop Med Public Health 36(2):370–377PubMedGoogle Scholar
  30. Dash PK et al (2006) Reemergence of dengue virus type-3 (subtype-III) in India: implications for increased incidence of DHF & DSS. Virol J 3:55PubMedCrossRefGoogle Scholar
  31. Dash PK et al (2011) Emergence of dengue virus type 4 (genotype I) in India. Epidemiol Infect 139(6):857–861PubMedCrossRefGoogle Scholar
  32. Deen JL et al (2006) The WHO dengue classification and case definitions: time for a reassessment. Lancet 368(9530):170–173PubMedCrossRefGoogle Scholar
  33. Dhiman RC, Pahwa S, Dhillon GP, Dash AP (2010) Climate change and threat of vector-borne diseases in India: are we prepared? Parasitol Res 106(4):763–773PubMedCrossRefGoogle Scholar
  34. Dhingra N et al (2010) Adult and child malaria mortality in India: a nationally representative mortality survey. Lancet 376(9754):1768–1774PubMedCrossRefGoogle Scholar
  35. Dhole TN, Mishra V (2012) Polio eradication in India. Proc Natl Acad Sci India Sect B (Biol Sci) 82(1):1–11Google Scholar
  36. Dutta P, Khan SA, Sharma CK, Doloi P, Hazarika NC, Mahanta J (1998) Distribution of potential dengue vectors in major townships along the national highways and trunk roads of northeast India. Southeast Asian J Trop Med Public Health 29(1):173–176PubMedGoogle Scholar
  37. Erum K, Mehreen K, Nabil K, Amna N, Salma A, Rumina H (2010) Demographic and clinical features of dengue fever in Pakistan from 2003–2007: a retrospective cross-sectional study. PLoS One 5(9):1–7Google Scholar
  38. Garg P, Nagpal J, Khairnar P, Seneviratne SL (2008) Economic burden of dengue infections in India. Trans R Soc Trop Med Hyg 102(6):570–577PubMedCrossRefGoogle Scholar
  39. Garg A, Garg J, Rao YK, Upadhyay GC, Sakhuja S (2011) Prevalence of dengue among clinically suspected febrile episodes at a teaching hospital in North India. J Inf Dis Immun 3:85–89Google Scholar
  40. Gill PS, Deep A, Chaudhary U, Gill M, Singh H (2008) An outbreak of dengue fever at a tertiary care centre, Haryana, India: a triggered catastrophe in 2006. Trop Med Health 36:143–147CrossRefGoogle Scholar
  41. Govindarajan M, Sivakumar R (2012) Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). Parasitol Res 110(5):1607–1620PubMedCrossRefGoogle Scholar
  42. Govindarajan M, Mathivanan T, Elumalai K, Krishnappa K, Anandan A (2011) Mosquito larvicidal, ovicidal, and repellent properties of botanical extracts against Anopheles stephensi, Aedes aegypti, and Culex quinquefasciatus (Diptera: Culicidae). Parasitol Res 109(2):353–367PubMedCrossRefGoogle Scholar
  43. Gratz NG (2004) Critical review of the vector status of Aedes albopictus. Med Vet Entomol 18(3):215–227PubMedCrossRefGoogle Scholar
  44. Gubler DJ, Clark GG (1995) Dengue/dengue hemorrhagic fever: the emergence of a global health problem. Emerg Infect Dis 1(2):55PubMedCrossRefGoogle Scholar
  45. Guha-Sapir D, Schimmer B (2005) Dengue fever: new paradigms for a changing epidemiology. Emerg Themes Epidemiol 2(1):1–10PubMedCrossRefGoogle Scholar
  46. Gupta P, Kumar P, Aggarwal OP (1998) Knowledge, attitude and practices related to dengue in rural and slum areas of Delhi after the dengue epidemic of 1996. J Commun Dis 30(2):107–112PubMedGoogle Scholar
  47. Gupta E, Dar L, Narang P, Srivastava VK, Broor S (2005) Serodiagnosis of dengue during an outbreak at a tertiary care hospital in Delhi. Indian J Med Res 121:36–38PubMedGoogle Scholar
  48. Gupta E, Dar L, Kapoor G, Broor S (2006) The changing epidemiology of dengue in Delhi, India. Virol J 3:92PubMedCrossRefGoogle Scholar
  49. Gupta N, Srivastava S, Jain A, Chaturvedi UC (2012) Dengue in India. Indian J Med Res 136(3):373–390PubMedGoogle Scholar
  50. Guy B, Saville M, Lang J (2010) Development of Sanofi Pasteur tetravalent dengue vaccine. Hum Vaccin 6(9):696–705CrossRefGoogle Scholar
  51. Guy B, Barrere B, Malinowski C, Saville M, Teyssou R, Lang J (2011) From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine. Vaccine 29(42):7229–7241PubMedCrossRefGoogle Scholar
  52. Guzmán MG, Kouri G (2002) Dengue: an update. Lancet Infect Dis 2(1):33–42PubMedCrossRefGoogle Scholar
  53. Guzman MG et al (2010) Dengue: a continuing global threat. Nat Rev Microbiol 8:S7–S16PubMedCrossRefGoogle Scholar
  54. Halasa YA, Dogra V, Arora N, Tyagi B, Nandan D, Shepard DS (2011) Overcoming data limitations: design of a multicomponent study for estimating the economic burden of dengue in India. Dengue Bull 35:1–14Google Scholar
  55. Halstead SB (1997) Epidemiology of dengue and dengue hemorrhagic fever. CAB International, WallingfordGoogle Scholar
  56. Halstead SB (2012) Dengue vaccine development: a 75 % solution? Lancet 380:1535–1536PubMedCrossRefGoogle Scholar
  57. Harris AF et al (2011) Field performance of engineered male mosquitoes. Nat Biotechnol 29(11):1034–1037PubMedCrossRefGoogle Scholar
  58. Hoffmann AA et al (2011) Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission. Nature 476(7361):454–457PubMedCrossRefGoogle Scholar
  59. Horrigan L, Lawrence RS, Walker P (2002) How sustainable agriculture can address the environmental and human health harms of industrial agriculture. Environ Health Perspect 110(5):445–456PubMedCrossRefGoogle Scholar
  60. Hubalek Z (2008) Mosquito-borne viruses in Europe. Parasitol Res 103(Suppl 1):S29–S43PubMedCrossRefGoogle Scholar
  61. Jaiswal S, Khanna N, Swaminathan S (2004) High-level expression and one-step purification of recombinant dengue virus type 2 envelope domain III protein in Escherichia coli. Protein Expr Purif 33:80–91PubMedCrossRefGoogle Scholar
  62. Jansen A, Frank C, Koch J, Stark K (2008) Surveillance of vector-borne diseases in Germany: trends and challenges in the view of disease emergence and climate change. Parasitol Res 103:S11–S17PubMedCrossRefGoogle Scholar
  63. Kabilan L et al (2004) Field- and laboratory-based active dengue surveillance in Chennai, Tamil Nadu, India: observations before and during the 2001 dengue epidemic. Am J Infect Control 32(7):391–396PubMedCrossRefGoogle Scholar
  64. Kaur H, Prabhakar H, Mathew P, Marshalla R, Arya M (1997) Dengue haemorrhagic fever outbreak in October-November 1996 in Ludhiana, Punjab, India. Indian J Med Res 106:1–3PubMedGoogle Scholar
  65. Khanam S, Rajendra P, Khanna N, Swaminathan S (2007) An adenovirus prime/plasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes. BMC Biotechnol 15:7–10Google Scholar
  66. Kharya G, Yadav SP, Katewa S, Sachdeva A (2011) Management of severe refractory thrombocytopenia in dengue hemorrhagic fever with intravenous anti-D immune globulin. Pediatr Hematol Oncol 28(8):727–732PubMedCrossRefGoogle Scholar
  67. Khor CC et al (2011) Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. Nat Genet 43(11):1139–1141PubMedCrossRefGoogle Scholar
  68. Klasen J, Habedank B (2008) Vector-borne diseases and their control. Parasitol Res 103:S1–S2PubMedCrossRefGoogle Scholar
  69. Kumar A, Sharma SK, Padbidri VS, Thakare JP, Jain DC, Datta KK (2001) An outbreak of dengue fever in rural areas of northern India. J Commun Dis 33(4):274–281PubMedGoogle Scholar
  70. Kumar AV et al (2010) Studies on community knowledge and behavior following a dengue epidemic in Chennai city, Tamil Nadu, India. Trop Biomed 27(2):330–336Google Scholar
  71. Kumar S et al (2012) Molecular herbal inhibitors of dengue virus: an update. Int J Med Arom Plants 2(1):1–21Google Scholar
  72. Kumaria R, Chakravarti A (2005) Molecular detection and serotypic characterization of dengue viruses by single-tube multiplex reverse transcriptase–polymerase chain reaction. Diagn Microbiol Infect Dis 52(4):311–316PubMedCrossRefGoogle Scholar
  73. Kurukumbi M et al (2001) Seroepidemiology and active surveillance of dengue fever/dengue haemorrhagic fever in Delhi. Indian J Med Sci 55(3):149–156PubMedGoogle Scholar
  74. Lacroix R et al (2012) Open field release of genetically engineered sterile male Aedes aegypti in Malaysia. PLoS One 7(8):e42771PubMedCrossRefGoogle Scholar
  75. Loke H et al (2002) Susceptibility to dengue hemorrhagic fever in Vietnam: evidence of an association with variation in the vitamin d receptor and Fc gamma receptor IIa genes. AmJTrop Med Hyg 67(1):102–106Google Scholar
  76. Madanayake MP, Gunatilake J, Haji A, Iqbal MCM (2004) A GIS approach to generating a dengue risk map. Indian J Med Res 120:173–182Google Scholar
  77. Mahadev PV et al (1993) Dengue in Gujarat state, India during 1988 & 1989. Indian J Med Res 97:135–144PubMedGoogle Scholar
  78. Mahesh KP et al (2012) Mosquitocidal activity of Solanum xanthocarpum fruit extract and copepod Mesocyclops thermocyclopoides for the control of dengue vector Aedes aegypti. Parasitol Res 111(2):609–618CrossRefGoogle Scholar
  79. Maheswaran R, Ignacimuthu S (2012) A novel herbal formulation against dengue vector mosquitoes Aedes aegypti and Aedes albopictus. Parasitol Res 110(5):1801–1813PubMedCrossRefGoogle Scholar
  80. Makroo RN, Raina V, Kumar P, Kanth RK (2007) Role of platelet transfusion in the management of dengue patients in a tertiary care hospital. Asian J Transfus Sci 1(1):4–7PubMedCrossRefGoogle Scholar
  81. Mehendale SM, Risbud AR, Rao JA, Banerjee K (1991) Outbreak of dengue fever in rural areas of Parbhani district of Maharashtra (India). Indian J Med Res 93:6–11PubMedGoogle Scholar
  82. Miller N (2010) Recent progress in dengue vaccine research and development. Curr Opin Mol Therapeut 12(1):31–38Google Scholar
  83. Mishra B et al (2011) Utility of multiplex reverse transcriptase-polymerase chain reaction for diagnosis and serotypic characterization of dengue and chikungunya viruses in clinical samples. Diagn Microbiol Infect Dis 71(2):118–125PubMedCrossRefGoogle Scholar
  84. Monath TP (1994) Dengue: the risk to developed and developing countries. Proc Natl Acad Sci U S A 91(7):2395–2400PubMedCrossRefGoogle Scholar
  85. Mustafa M, Agrawal V (2008) Dengue vaccine: the current status. Med J Armed Forces India 64(2):161–164CrossRefGoogle Scholar
  86. Myers RM, Varkey MJ, Reuben R, Jesudass ES (1970) Dengue outbreak in Vellore, southern India, in 1968, with isolation of four dengue types from man and mosquitoes. Indian J Med Res 58(1):24–30PubMedGoogle Scholar
  87. Nandi J, Sharma RS, Dutta PK, Dhillon GPS (2008) Dengue in the National Capital Territory (NCT) of Delhi (India): epidemiological and entomological profile for the period 2003 to 2008. Dengue Bull 32:156–161Google Scholar
  88. Nimmannitya S (1995) Dengue fever/dengue haemorrhagic fever: case management. Trop Med 36(4):249–256Google Scholar
  89. Ooi EE, Gubler DJ (2008) Dengue in Southeast Asia: epidemiological characteristics and strategic challenges in disease prevention [Dengue no Sudeste Asiático: características epidemiológicas e desafios estratégicos na]. Cadernos de Saúde Pública 25(Sup 1):S115–S124Google Scholar
  90. Padbidri VS et al (1995) The 1993 epidemic of dengue fever in Mangalore, Karnataka state, India. Southeast Asian J Trop Med Public Health 26(4):699–704PubMedGoogle Scholar
  91. Padbidri VS et al (2002) A serological survey of arboviral diseases among the human population of the Andaman and Nicobar Islands, India. Southeast Asian J Trop Med Public Health 33(794–800)Google Scholar
  92. Paramasivan R, Thenmozhi V, Hiriyan J, Dhananjeyan K, Tyagi B, Dash AP (2006) Serological and entomological investigations of an outbreak of dengue fever in certain rural areas of Kanyakumari district, Tamil Nadu. Indian J Med Res 123(5):697–701PubMedGoogle Scholar
  93. Parida MM, Upadhyay C, Saxena P, Dash PK, Jana AM, Seth P (2001) Evaluation of a dipstick ELISA and a rapid immunochromatographic test for diagnosis of Dengue virus infection. Acta Virol 45:299–304PubMedGoogle Scholar
  94. Parida MM et al (2005) Rapid detection and differentiation of dengue virus serotypes by a real-time reverse transcription-loop-mediated isothermal amplification assay. J Clin Microbiol 43:2895–2903PubMedCrossRefGoogle Scholar
  95. Pates H, Curtis C (2005) Mosquito behavior and vector control. Annu Rev Entomol 50:53–70PubMedCrossRefGoogle Scholar
  96. Prasad MN, Mithilesh M, Rao GVR (2010) Public health surveillance in India—challenges and opportunities. Indian Emerg J 5:21–26Google Scholar
  97. Raghavendra K, Barik TK, Reddy BP, Sharma P, Dash AP (2011) Malaria vector control: from past to future. Parasitol Res 108(4):757–779PubMedCrossRefGoogle Scholar
  98. Raheel U et al (2011) Dengue fever in the Indian subcontinent: an overview. J Infect Dev Ctries 5(4):239–247PubMedGoogle Scholar
  99. Rajkumar S, Jebanesan A (2010) Prevention of Dengue fever through plant based mosquito repellent Clausena dentata (Willd.) M. Roem (Family: Rutaceae) essential oil against Aedes aegypti L. (Diptera: Culicidae) mosquito. Eur Rev Med Pharmacol Sci 14(3):231–234PubMedGoogle Scholar
  100. Raju KPBPLN, Sokhi BS (2008) Application of GIS modeling for dengue fever prone area based on socio-cultural and environmental factors—a case study of delhi city zone. Int Arch Photogramm Remote Sens Spat Inf Sci XXXVII:165–170Google Scholar
  101. Ranjit S, Kissoon N, Shamarao S (2009) Dengue viral infections and shock syndromes: an overview. J Pediatr Infect Dis 4(2):107–117Google Scholar
  102. Rao CV (1987) Dengue fever in India. Indian J Pediatr 54(1):11–14PubMedCrossRefGoogle Scholar
  103. Rasgon JL (2011) Mosquitoes attacked from within. Nature 476:407–408PubMedCrossRefGoogle Scholar
  104. Ravikumar H et al (2010) A preliminary survey for Wolbachia and bacteriophage WO infections in Indian mosquitoes (Diptera: Culicidae). Trop Biomed 27:384–393PubMedGoogle Scholar
  105. Sabchareon A et al (2012) Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial. Lancet 380:1559–1567PubMedCrossRefGoogle Scholar
  106. Sakuntabhai A et al (2005) A variant in the CD209 promoter is associated with severity of dengue disease. Nat Genet 37(5):507–513PubMedCrossRefGoogle Scholar
  107. Sarkar JK, Pavri KM, Chatterjee SN, Chakravarty SK, Anderson CR (1964) Virological and serological studies of cases of haemorrhagic fever in Calcutta. Indian J Med Res 52:684–691PubMedGoogle Scholar
  108. Saxena P, Dash PK, Santhosh SR, Srivastava A, Parida MM, Rao PVL (2008) Development and evaluation of one step single tube multiplex RT-PCR for rapid detection and typing of dengue viruses. Virol J 5:20PubMedCrossRefGoogle Scholar
  109. Schmitz J, Roehrig J, Barrett A, Hombach J (2011) Next generation dengue vaccines: a review of candidates in preclinical development. Vaccine 29(42):7276–7284PubMedCrossRefGoogle Scholar
  110. Seppa N (2012) Body & brain: dengue vaccine trial disappoints: shots protect against three virus subtypes, not fourth. Sci News 182(8):18CrossRefGoogle Scholar
  111. Shepard DS et al (2004) Cost-effectiveness of a pediatric dengue vaccine. Vaccine 22(9):1275–1280PubMedCrossRefGoogle Scholar
  112. Singh MS, Bharadwaj A (2000) Communicating immunisation: the mass media strategies. Econ Polit Wkly 35:667–675Google Scholar
  113. Singh J et al (2000) Silent spread of dengue and dengue haemorrhagic fever to Coimbatore and Erode districts in Tamil Nadu, India, 1998: need for effective surveillance to monitor and control the disease. Epidemiol Infect 125(1):195–200PubMedCrossRefGoogle Scholar
  114. Singh MM, Bano T, Dabas P, Mehra M (2001) Awareness about pulse polio immunization among the general population in Delhi. Indian J Med Sci 55(8):453–457PubMedGoogle Scholar
  115. Singh RK, Dhiman RC, Dua VK, Joshi BC (2010) Entomological investigations during an outbreak of dengue fever in Lal Kuan town, Nainital district of Uttarakhand, India. J Vector Borne Dis 47:189–192PubMedGoogle Scholar
  116. Sivagnaname N, Yuvarajan S, De Britto RLJ (2012) Urgent need for a permanent dengue surveillance system in India. Curr Sci 102(5):672–675Google Scholar
  117. Soni A, Chugh K, Sachdev A, Gupta D (2001) Management of dengue fever in ICU. Indian J Pediatr 68(11):1051–1055PubMedCrossRefGoogle Scholar
  118. Sunish IP, Rajendran R, Paramasivan R, Dhananjeyan KJ, Tyagi BK (2011) Wolbachia endobacteria in a natural population of Culex quinquefasciatus from filariasis endemic villages of south India and its phylogenetic implication. Trop Biomed 28(3):569–576PubMedGoogle Scholar
  119. Swaminathan S, Khanna N (2003) Viral vaccines for dengue: the present and the future. Dengue Bull 27:181–191Google Scholar
  120. Teixeira MG, Barreto ML, Costa MCN, Ferreira LDA, Vasconcelos PFC, Cairncross S (2002) Dynamics of dengue virus circulation: a silent epidemic in a complex urban area. Trop Med Int Health 7(9):757–762CrossRefGoogle Scholar
  121. Tewari SC, Thenmozhi V, Katholi CR, Manavalan R, Munirathinam A, Gajanana A (2004) Dengue vector prevalence and virus infection in a rural area in south India. Trop Med Int Health 9(4):499–507PubMedCrossRefGoogle Scholar
  122. Thenmozhi V, Tewari SC, Manavalan R, Balasubramanian A, Gajanana A (2000) Natural vertical transmission of dengue viruses in Aedes aegypti in southern India. Trans R Soc Trop Med Hyg 94(5):507PubMedCrossRefGoogle Scholar
  123. Tikar SN, Mendki MJ, Chandel K, Parashar BD, Prakash S (2008) Susceptibility of immature stages of Aedes (Stegomyia) aegypti; vector of dengue and chikungunya to insecticides from India. Parasitol Res 102(5):907–913PubMedCrossRefGoogle Scholar
  124. Tikar SN, Kumar A, Prasad GB, Prakash S (2009) Temephos-induced resistance in Aedes aegypti and its cross-resistance studies to certain insecticides from India. Parasitol Res 105(1):57–63PubMedCrossRefGoogle Scholar
  125. Ukey PM, Bondade SA, Paunipagar PV, Powar RM, Akulwar SL (2010) Study of seroprevalence of dengue fever in central India. Indian J Community Med 35(4):517–519PubMedCrossRefGoogle Scholar
  126. Vajpayee M, Singh UB, Seth P, Broor S (2001) Comparative evaluation of various commercial assays for diagnosis of dengue fever. Southeast Asian J Trop Med Public Health 32:472–475PubMedGoogle Scholar
  127. Victor TJ et al (2002) Dengue fever outbreaks in two villages of Dharmapuri district in Tamil Nadu. Indian J Med Res 116:133–139PubMedGoogle Scholar
  128. Walker T et al (2011) The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations. Nature 476(7361):450–453PubMedCrossRefGoogle Scholar
  129. Webster DP, Farrar J, Rowland-Jones S (2009) Progress towards a dengue vaccine. Lancet Infect Dis 9(11):678–687PubMedCrossRefGoogle Scholar
  130. WHO (2002) DengueNet—WHOs internet-based system for global surveillance of dengue fever and dengue haemorrhagic fever (dengue/DHF). Weekly Epidemiol Rec 77:301–304Google Scholar
  131. WHO (2004) Dengue Net in India. Wkly Epidemiol Rec 79:57–62Google Scholar
  132. WHO (2009) Global strategy for dengue prevention and control. Geneva, World Health Organization. http://whqlibdocwhoint/publications/2009/9789241547871_engpdf. Accessed Apr 2012
  133. Wilder-Smith A, Ooi EE, Vasudevan SG, Gubler DJ (2010) Update on dengue: epidemiology, virus evolution, antiviral drugs, and vaccine development. Curr Infect Dis Rep 12(3):157–164PubMedCrossRefGoogle Scholar
  134. Yadava RL, Narasimhan MVL (1992) Dengue/DHF and its control in India. Dengue Newsletter 17:3–8Google Scholar

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Agriculture DepartmentJammuIndia
  2. 2.School of Studies in BiotechnologyJiwaji UniversityGwaliorIndia

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