Parasitology Research

, Volume 110, Issue 6, pp 2551–2556

Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species

  • Tábitha Dahmer Rocha
  • Patrícia de Brum Vieira
  • Simone Cristina Baggio Gnoatto
  • Tiana Tasca
  • Grace Gosmann
Original Paper

Abstract

Trichomonas vaginalis is a flagellated protozoan that causes trichomonosis, the most prevalent non-viral STD worldwide. The pathogen has been associated with serious health consequences including predisposition to cervical cancer and adverse pregnancy outcomes and infertility. It also acts as a co-factor in HIV transmission and acquisition. The 5-nitroimidazole drugs are used in the treatment, however, treatment noncompliance is observed, and a growing number of T. vaginalis isolates resistant to the drugs have been related. Saponins are natural products possessing many biological activities such as antiprotozoan activity. The aim of this study was to evaluate the anti-T. vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species. Saponins from Passiflora alata and Quillaja saponaria presented the best anti-T. vaginalis activity (MIC = 0.025%). In addition, all samples induced erythrocyte lysis and LDH release. As far as we know, this is the first report demonstrating the potential anti-T. vaginalis activity of these saponins.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Tábitha Dahmer Rocha
    • 1
  • Patrícia de Brum Vieira
    • 2
  • Simone Cristina Baggio Gnoatto
    • 1
  • Tiana Tasca
    • 2
  • Grace Gosmann
    • 1
  1. 1.Laboratório de Fitoquímica e Síntese Orgânica, Departamento de Produção de Matéria-Prima, Faculdade de FarmáciaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Laboratório de Pesquisa em Parasitologia, Departamento de Análises, Faculdade de FarmáciaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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