Parasitology Research

, Volume 110, Issue 5, pp 1779–1783 | Cite as

In vitro antileishmanial and antitrypanosomal activities of five medicinal plants from Burkina Faso

  • W. R. Sawadogo
  • G. Le Douaron
  • A. Maciuk
  • C. Bories
  • P. M. Loiseau
  • B. Figadère
  • I. P. Guissou
  • O. G. Nacoulma
Original Paper

Abstract

After ethnobotanical surveys in central and western regions of Burkina Faso, five plants namely Lantana ukambensis (Verbenaceae), Xeoderris sthulmannii (Fabaceae), Parinari curatellifollia (Chrysobalanaceae), Ozoroa insignis (Anacardiaceae), and Ficus platyphylla (Moraceae) were selected for their traditional use in the treatment of parasitic diseases and cancer. Our previous studies have focused on the phytochemical, genotoxicity, antioxidant, and antiproliferative activities of these plants. In this study, the methanol extract of each plant was tested to reveal probable antileishmanial and antitrypanosomal activities. Colorimetric and spectrophotometric methods were used for the detection of antileishmanial and antitrypanosomal activities. Leishmania donovani (LV9 WT) and Trypanosoma brucei brucei GVR 35 were used to test the antileishmanial and antitrypanosomal activities, respectively. All extracts of tested plants showed a significant antitrypanosomal activity with minimum lethal concentrations between 1.5 and 25 μg/ml, the L. ukambensis extract being the most active. In the antileishmanial test, only the extract from L. ukambensis showed significant activity with an inhibitory concentration (IC50) of 6.9 μg/ml. The results of this study contribute to the promotion of traditional medicine products and are preliminary for the isolation of new natural molecules for the treatment of leishmaniasis and trypanosomiasis.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • W. R. Sawadogo
    • 1
    • 2
  • G. Le Douaron
    • 2
  • A. Maciuk
    • 2
  • C. Bories
    • 3
  • P. M. Loiseau
    • 3
  • B. Figadère
    • 2
  • I. P. Guissou
    • 1
    • 4
  • O. G. Nacoulma
    • 5
  1. 1.Institut de Recherche en Sciences de la Santé (IRSS/CNRST)Ouagadougou 03Burkina Faso
  2. 2.Laboratoire de chimie des substances naturelles, UMR-8076 BioCis, Labex LERMIT, Faculté de Pharmacie de Châtenay-MalabryUniv Paris-SudChâtenay-MalabryFrance
  3. 3.Chimiothérapie antiparasitaire/UMR-8076 BioCis, Labex LERMIT, Faculté de Pharmacie de Châtenay-MalabryUniv Paris-SudChâtenay-MalabryFrance
  4. 4.Département de Sciences Pharmaceutiques appliquées/Pharmacologie–toxicologieUFR/SDS/Université de OuagadougouOuagadougouBurkina Faso
  5. 5.Laboratoire de Biochimie et Chimie appliquéesUFR/SVT Université de OuagadougouOuagadougouBurkina Faso

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