In vitro antileishmanial and antitrypanosomal activities of five medicinal plants from Burkina Faso
- 296 Downloads
After ethnobotanical surveys in central and western regions of Burkina Faso, five plants namely Lantana ukambensis (Verbenaceae), Xeoderris sthulmannii (Fabaceae), Parinari curatellifollia (Chrysobalanaceae), Ozoroa insignis (Anacardiaceae), and Ficus platyphylla (Moraceae) were selected for their traditional use in the treatment of parasitic diseases and cancer. Our previous studies have focused on the phytochemical, genotoxicity, antioxidant, and antiproliferative activities of these plants. In this study, the methanol extract of each plant was tested to reveal probable antileishmanial and antitrypanosomal activities. Colorimetric and spectrophotometric methods were used for the detection of antileishmanial and antitrypanosomal activities. Leishmania donovani (LV9 WT) and Trypanosoma brucei brucei GVR 35 were used to test the antileishmanial and antitrypanosomal activities, respectively. All extracts of tested plants showed a significant antitrypanosomal activity with minimum lethal concentrations between 1.5 and 25 μg/ml, the L. ukambensis extract being the most active. In the antileishmanial test, only the extract from L. ukambensis showed significant activity with an inhibitory concentration (IC50) of 6.9 μg/ml. The results of this study contribute to the promotion of traditional medicine products and are preliminary for the isolation of new natural molecules for the treatment of leishmaniasis and trypanosomiasis.
KeywordsVisceral Leishmaniasis Leishmaniasis Pentamidine Cutaneous Leishmaniasis African Human Trypanosomiasis
We are grateful to the Agence Universitaire de la Francophonie (AUF) for providing financial support (postdoctoral grant).
- Farnsworth NR, Akelere O, Bingel A, Soejarto DD, Guo Z (1985) Medicinal plants in therapy. In: WHO (ed) WHO Bull 63:965–981Google Scholar
- González-Coloma A, et al (2011) Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants. Parasitol Res in press doi: 10.1007/s00436-011-2638-3
- Sawadogo WR et al (2011) Mutagenic effect, antioxidant and anticancer activities of six medicinal plants from Burkina Faso. Nat Prod Res. doi: 10.1080/14786419.2010.534737
- WHO (1998) Control and surveillance of African trypanosomiasis. WHO Tech Rep Ser. vol 881. World Health Organisation, GenevaGoogle Scholar
- WHO (2003) Traditional medicine fact sheet, vol 134. WHO, GenevaGoogle Scholar