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Parasitology Research

, Volume 109, Issue 4, pp 969–979 | Cite as

Capillaria hepatica in man—an overview of hepatic capillariosis and spurious infections

  • Hans-Peter Fuehrer
  • Petra Igel
  • Herbert AuerEmail author
Review

Abstract

Capillaria hepatica (syn. for Calodium hepaticum) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.

Keywords

Ivermectin Albendazole Echinococcus Thiabendazole Echinococcus Granulosus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We would like to thank Scott Northrup and Paul Swoboda for proofreading.

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. Anonymous (1993) Mexico: Capillaria hepatica in Rats and Acapulcan Children, 1993. http://www.ciet.org/en/project/mexico-capillaria-hepatica-in-rats-and-acapulcan-children-1993/. Accessed: 27 Feb. 2011
  2. Assis BC, Cunha LM, Baptista AP, Andrade ZA (2004) A contribution to the diagnosis of Capillaria hepatica infection by indirect immunofluorescence test. Mem Inst Oswaldo Cruz 99(2):173–177PubMedCrossRefGoogle Scholar
  3. Attah EB, Nagarajan S, Obineche EN, Gera SC (1983) Hepatic capillariasis. Am J Clin Pathol 79:127–130PubMedGoogle Scholar
  4. Berger T, Degrémont A, Gebbers JO, Tönz O (1990) Hepatic capillariasis in a 1-year-old child. Eur J Pediatr 149(5):333–336PubMedCrossRefGoogle Scholar
  5. Brosius OT, Thomas EE, Brosius B (1948) Capillaria hepatica; a case report. Trans Roy Soc Trop Med and Hyg 42:95–97, In Lubinsky (1956)CrossRefGoogle Scholar
  6. Bustamente-Sarabia J, Suswillo R, Contreras-Moreno E (1996) Capillaria hepatica in a 19-month old boy, third case in Mexico. Bol Med Hosp Infant Mex 53:395–400Google Scholar
  7. Calle S (1961) Parasitism by Capillaria hepatica. Pediatrics 27:648–655PubMedGoogle Scholar
  8. Camain R, Dor X, Ranavo F (1965) Infestation hépatique à Capillaria hepatica chez un enfant de 11 mois. Ann Pediatr (Paris) 12:559–562Google Scholar
  9. Camargo LM, de Souza Almeida Aranha Camargo J, Vera LJ, di Tarique Crispim Barreto P, Tourinho EK, de Souza MM (2010) Capillariaisis (Trichurida, Trichinellidae, Capillaria hepatica) in the Brazilian Amazon: low pathogenicity, low infectivity and a novel mode of transmission. Parasit Vectors 3:11PubMedCrossRefGoogle Scholar
  10. Choe G, Lee HS, Seo JK, Chai JY, Lee SH, Eom KS, Chi JG (1993) Hepatic capillariasis: first case report in the Republic of Korea. Am J Trop Med Hyg 48(5):610–625, ReviewPubMedGoogle Scholar
  11. Cislaghi F, Radice C (1970) Infection by Capillaria hepatica. First case report in Italy. Helv Paediatr Acta 25(6):647–654PubMedGoogle Scholar
  12. Cislaghi F, Radice C (1971) [Infestations by capillaria hepatica. 1st in vivo observation in Italy]. Minerva Pediatr 23(14):605, In ItalianPubMedGoogle Scholar
  13. Cochrane JC, Skinstad EE (1960) Capillaria hepatica in man-follow-up of a case. S Afr Med J 34:21–22PubMedGoogle Scholar
  14. Cochrane JC, Sagorin L, Wilcocks MG (1957) Capillaria hepatica infection in man; a syndrome of extreme eosinophilia, hepatomegaly and hyperglobulinaemia. S Afr Med J 31(30):751–755PubMedGoogle Scholar
  15. Coimbra CE Jr, Mello DA (1981) [Enteroparasites and Capillaria sp. among the Suruí tribe, Parque Indígena Aripuanã, Rondônia]. Mem Inst Oswaldo Cruz 76(3):299–302, In PortuguesePubMedCrossRefGoogle Scholar
  16. Dive GH, LaFrenais HM, MacArthur WP (1924) A case of deposition of the eggs of Hepaticola hepatica in the human liver. J R Army Med Corps 43:1–4Google Scholar
  17. Eaton RDP (1972) Current problems in parasitology in Canadian native peoples. Acta Sociomed Scand Suppl 6:249–253, Review; in Juncker-Voss et al. (2000)PubMedGoogle Scholar
  18. Engler G, Sanchez G (1950) Capillaria hepatica (Bancroft, 1893); a case report. Trans Roy Soc Trop Med Hyg 43:443–444, In Lubinsky (1956)PubMedCrossRefGoogle Scholar
  19. Ewing GM, Tilden IL (1956) Capillaria hepatica; report of fourth case of true human infestation. J Pediatr 48(3):341–348PubMedCrossRefGoogle Scholar
  20. Fan PC, Chung WC, Chen ER (2000) Capillaria hepatica: a spurious case with a brief review. Kaohsiung J Med Sci 16(7):360–367, ReviewPubMedGoogle Scholar
  21. Fauna Europaea (2011) Taxonomy of Calodium hepaticum. http://www.faunaeur.org/full_results.php?id=392583. Accessed 27 Feb 2011
  22. Faust EC (1931) Investigations in Panama during the summer of 1930. Science 73:43–45, In Lubinsky (1956)PubMedCrossRefGoogle Scholar
  23. Faust EC, Martinez WH (1935) Notes on helminths from Panama. II. Rare human nematode eggs in the feces of individuals from the Chagres River, Panama. J Parasit 21:332–336, In Lubinsky (1956)CrossRefGoogle Scholar
  24. Foster AO, Johnson CM (1939) An explanation for the occurrence of Capillaria hepatica ova in human faeces suggested by the finding of three new hosts used as food. Trans Roy Soc Trop Med Hyg 32:639–644CrossRefGoogle Scholar
  25. Fugassa MH, Taglioretti V, Gonçalves ML, Araújo A, Sardella NH, Denegri GM (2008) Capillaria spp. eggs in Patagonian archaeological sites: statistical analysis of morphometric data. Mem Inst Oswaldo Cruz 103(1):104–105PubMedCrossRefGoogle Scholar
  26. Führer HP, Schneider R, Walochnik J, Auer H (2010) Extraintestinal helminths of the common vole (Microtus arvalis) and the water vole (Arvicola terrestris) in Western Austria (Vorarlberg). Parasitol Res 106(4):1001–1004PubMedCrossRefGoogle Scholar
  27. Galvão VA (1981) [Capillaria hepatica: an evaluation of its pathogenic role in man]. Mem Inst Oswaldo Cruz 76(4):415–433, In PortuguesePubMedCrossRefGoogle Scholar
  28. González Barranco D, Peláez D, Jaramillo Rodríguez Y, Rodríguez-Martínez HA (1996) Third case of human hepatic capillariasis in Mexico. Rev Invest Clin 48(4):301–305, In SpanishPubMedGoogle Scholar
  29. Govil H, Desai M (1996) Capillaria hepatica parasitism. Indian J Pediatr 63(5):698–700PubMedCrossRefGoogle Scholar
  30. Huang JN, Lin JX (2004) The pathological diagnosis of the first case of Capillaria hepatica in Fujian province. Zhongguo Renshou Gonghuanbing Zazhi 20:556, In Li et al. (2010)Google Scholar
  31. Juncker-Voss M, Prosl H, Lussy H, Enzenberg U, Auer H, Nowotny N (2000) Serological detection of Capillaria hepatica by indirect immunofluorescence assay. J Clin Microbiol 38(1):431–433, ReviewPubMedGoogle Scholar
  32. Juncker-Voss M, Prosl H, Lussy H, Enzenberg U, Auer H, Lassnig H, Müller M, Nowotny N (2004) Screening for antibodies against zoonotic agents among employees of the Zoological Garden of Vienna, Schönbrunn, Austria. Berl Munch Tierarztl Wochenschr 117(9–10):404–409, In GermanPubMedGoogle Scholar
  33. Kallichurum S, Elsdon-Dew R (1961) Capillaria in man. A case report. S Afr Med J 35:860–861PubMedGoogle Scholar
  34. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL (2005) Harrison's principles of internal medicine, 16th edn. McGraw-Hill, New YorkGoogle Scholar
  35. Keven K, Bengisun JS, Altuntaş F, Akar H, Nergizoğlu G, Kutlay S, Duman N, Erbay B (2001) Cystic infection of the liver in a maintenance haemodialysis patient. Nephrol Dial Transplant 16(4):859–860PubMedCrossRefGoogle Scholar
  36. Kim MK, Kim CH, Yeom BW, Park SH, Choi SY, Choi JS (2002) The first human case of hepatic dirofilariasis. J Korean Med Sci 17(5):686–690PubMedGoogle Scholar
  37. Klenzak J, Mattia A, Valenti A, Goldberg J (2005) Hepatic capillariasis in Maine presenting as a hepatic mass. Am J Trop Med Hyg 72(5):651–653PubMedGoogle Scholar
  38. Koea J, Smith D (2008) Solitary necrotic nodule revisited. ANZ J Surg 78(1–2):109–111PubMedCrossRefGoogle Scholar
  39. Kohatsu H, Zaha O, Shimada K, Chibana T, Yara I, Shimada A, Hasegawa H, Sato Y (1995) A space-occupying lesion in the liver due to Capillaria infection. Am J Trop Med Hyg 52(5):414–418PubMedGoogle Scholar
  40. Kokai GK, Misic S, Perisic VN, Grujovska S (1990) Capillaria hepatica infestation in a 2-year-old girl. Histopathology 17(3):275–277PubMedCrossRefGoogle Scholar
  41. Li CD, Yang HL, Wang Y (2010) Capillaria hepatica in China. World J Gastroenterol 16(6):698–702PubMedCrossRefGoogle Scholar
  42. Lim JH (2008) Toxocariasis of the liver: visceral larva migrans. Abdom Imaging 33(2):151–156, ReviewPubMedCrossRefGoogle Scholar
  43. Lin XM, Li H, Zhao XD, Lin XD, Li H, Zhao XD, Deng Y (2004) 1 case of Capillaria hepatica infection. Zhongguo Jishengchongbing Fanghzhi Zahi: 17:230, In Li et al. (2010)Google Scholar
  44. Lubinsky G (1956) On the probable presence of parasitic liver cirrhoses in Canada. Can J Comp Med 20:457–465PubMedGoogle Scholar
  45. MacArthur WP (1924) A case of infestation of human liver with Hepaticola hepatica (Bancroft, 1893), Hall, 1916; with sections from the liver. Proc R Soc Med 17:83–84, Sect Trop Dis ParasitolPubMedGoogle Scholar
  46. Machado ER, Santos DS, Costa-Cruz JM (2008) Enteroparasites and commensals among children in four peripheral districts of Uberlândia, State of Minas Gerais. Rev Soc Bras Med Trop 41(6):581–585PubMedCrossRefGoogle Scholar
  47. McQuown AL (1950) Capillaria hepatica; report of genuine and spurious cases. Am J Trop Med Hyg 30(5):761–767PubMedGoogle Scholar
  48. McQuown AL (1954) Capillaria hepatica. Am J Clin Pathol 24(4):448–452PubMedGoogle Scholar
  49. Moravec F (1982) Proposal of a new systematic arrangement of nematodes of the family Capillariidae. Folia Parasitol (Praha) 29:119–132Google Scholar
  50. Moravec F, Garibaldi F (2000) Huffmanela paronai sp. n. (Nematoda: Trichosomoididae), a new parasite from the skin of swordfish Xiphias gladius in the Ligurian sea (Western Mediterranean). Folia Parasitol (Praha) 47(4):309–313Google Scholar
  51. Müller JG, Kirchner T, Pannenbecker J, Müller-Hermelink HK (1990) [Hepatic capillariasis. Morphology and differential diagnosis]. Pathologe 11(5):300–303, In GermanPubMedGoogle Scholar
  52. Nabi F, Palaha HK, Sekhsaria D, Chiatale A (2007) Capillaria hepatica infestation. Indian Pediatr 44(10):781–782PubMedGoogle Scholar
  53. Odunjo EO (1970) Helminthic anaphylactic syndrome (HAS) in children. Pathol Microbiol (Basel) 35(1):220–223, In Schmidt (2001)Google Scholar
  54. Orihuela-Chávez OE, Reyna-Figueroa J, Wakida-Kusunoki G, Limón-Rojas AE, Pasquel P, Nava-Jácome R (2006) Capilariasis hepática en niños: reporte del cuarto caso en México. Enf Infec Microbiol 26(3):86–88, In SpanishGoogle Scholar
  55. Otto GF, Berthrong M, Appleby RE, Rawlins JC, Wilbur O (1954) Eosinophilia and hepatomegaly due to Capillaria hepatica infection. Bull Johns Hopkins Hosp 94(6):319–336PubMedGoogle Scholar
  56. Palhano-Silva CS, Araújo AJG, Lourenço AEP, Bastos OMP, Santos RV, Coimbra CEA Jr (2009) Intestinal parasitic infection in the Surui Indians, Brazilian Amazon. Interciencia 34(4):259–264Google Scholar
  57. Pampiglione S, Conconi G (1970) Primo caso Capillariosi epatica osservata nell'uomo in Italia. Parassitologia 12:125–134, In Schmidt (2001)Google Scholar
  58. Pampiglione S, Gustinelli A (2008) Human hepatic capillariasis: a second case occurred in Korea. J Korean Med Sci 23(3):560–561, Author reply 561PubMedCrossRefGoogle Scholar
  59. Pannenbecker J, Miller TC, Müller J, Jeschke R (1990) [Severe liver involvement by Capillaria hepatica]. Monatsschr Kinderheilkd 138(11):767–771, In GermanPubMedGoogle Scholar
  60. Pereira VG, França LC (1981) [Human Capillaria hepatica infection. Report of a case treated successfully]. Rev Hosp Clin Fac Med Sao Paulo 36(1):31–34, In PortuguesePubMedGoogle Scholar
  61. Pereira VG, Mattosinho Franca LC (1983) Successful treatment of Capillaria hepatica infection in an acutely ill adult. Am J Trop Med Hyg 32(6):1272–1274PubMedGoogle Scholar
  62. Piazza R, Correa MO, Fleury RN (1963) [On a case of human infestation with Capillaria hepatica]. Rev Inst Med Trop Sao Paulo 5:37–41, In Portuguese; in Choe et al. (1993)PubMedGoogle Scholar
  63. Romero Garcia F, Mendiola J, Biaji F (1962) [Elevated eosinophilia with visceral manifestation. IV. 1st case of Capillaria hepatica infection reported in Mexico]. Bol Med Hosp Infant Mex 19(19):473–479, In Spanish; in Schmidt (2001)PubMedGoogle Scholar
  64. Sandground JH (1933) Parasitic nematodes from East Africa and Southern Rhodesia. Bull Mus Comp Zool (Harvard) 15:263–293, In Lubinsky (1956)Google Scholar
  65. Sawamura R, Fernandes MI, Peres LC, Galvão LC, Goldani HA, Jorge SM, de Melo RG, de Souza NM (1999) Hepatic capillariasis in children: report of 3 cases in Brazil. Am J Trop Med Hyg 61(4):642–647PubMedGoogle Scholar
  66. Schmidt S (2001) Untersuchungen zum Vorkommen von Capillaria hepatica und Metazestoden der Cyclophyllida bei Wildmäusen in Deutschland. PhD Thesis, Universität., Veterinärmedizinische Fakultät, Leipzig: 145 ppGoogle Scholar
  67. Schouten H, Suriel-Smeets RM, Kibbelaar MA (1968) The simultaneous occurrence of ova resembling Dicrocoelium dentriticum or Capillaria hepatica in the stools of inhabitants of Curaço. Trop Geogr Med 20(3):271–275PubMedGoogle Scholar
  68. Sekikawa H, Hasegawa H, Otsuru M, Igarashi T, Kaneko H, Wada K, Sato O, Wakakuwa R, Tajima K, Homma K (1991) First human case of Capillaria hepatica infection in Japan. Jpn J Parasitol 40:528–532Google Scholar
  69. Sianto L, Chame M, Silva CS, Gonçalves ML, Reinhard K, Fugassa M, Araújo A (2009) Animal helminths in human archaeological remains: a review of zoonoses in the past. Rev Inst Med Trop Sao Paulo 51(3):119–130PubMedCrossRefGoogle Scholar
  70. Silverman NH, Katz JS, Levin SE (1973) Capillaria hepatica infestation in a child. S Afr Med J 47(6):219–221PubMedGoogle Scholar
  71. Skrjabin KL, Podiapolskala VP, Shikhobalova NP (1929) Neue Faelle der Hepaticolosis beim Menschen. Russk Zhurnal Trop Med 7:449–450, In Lubinsky (1956)Google Scholar
  72. Šlais J (1973) The finding and identification of solitary Capillaria hepatica (Bancroft, 1893) in man from Europe. Folia Parasitol (Praha) 20(2):149–161Google Scholar
  73. Šlais J (1974) Notes on the differentiation of Capillaria hepatica and visceral larva migrans. Folia Parasitol (Praha) 21:95Google Scholar
  74. Šlais J, Stĕrba J (1972) Solitary liver granulomas in man caused by Capillaria hepatica (Bancroft, 1893) in Czechoslovakia. Folia Parasitol (Praha) 19(4):373–374Google Scholar
  75. Sumner D, Tinsley EG (1967) Encephalopathy due to visceral larva migrans. J Neurol Neurosurg Psychiatry 30(6):580–584PubMedCrossRefGoogle Scholar
  76. Terrier P, Hack I, Hatz C, Theintz G, Roulet M (1999) Hepatic capillariasis in a 2-year-old boy. J Pediatr Gastroenterol Nutr 28(3):338–340PubMedCrossRefGoogle Scholar
  77. Tesana S, Puapairoj A, Saeseow O (2007) Granulomatous, hepatolithiasis and hepatomegaly caused by Capillaria hepatica infection: first case report of Thailand. Southeast Asian J Trop Med Public Health 38(4):636–640PubMedGoogle Scholar
  78. Turhan B, Unat EK, Yenermen M, Simmer C (1954) Insan Karacigerinde Capillaria hepatica (BANCROFT, 1893) TRAVASSOS 1915. Mikrobiologie Dergisi 7: 149–159. In Ward and Dent (1959)Google Scholar
  79. Vargas Carreto G, López Martínez H, Victoria Victoria R, Hernández Muñoz G (1979) [Capillaria hepatica. Report of the 2nd cased found in the Mexican Republic]. Bol Med Hosp Infant Mex 36(5):909–917, In SpanishPubMedGoogle Scholar
  80. Vogel H (1932) Beitraege zur Epidemiologie der Schistosomiasis in Liberia and Franzossich-Guinea. Arch. Schiffs- u. Tropen-Hyg. 36 108,135. In Lubinsky (1956)Google Scholar
  81. Ward RL, Dent JH (1959) Capillaria hepatica infection in a child. Bull Tulane Univ Med Fac 19:27–33PubMedGoogle Scholar
  82. Wright HE (1938) Further observations on the incidence of Hepaticola (Capillaria) hepatica ova in human feces. Amer J Trop Med 18:329–330, In Lubinsky (1956)Google Scholar
  83. Xu BK, Li DN (1979) General condition on the rare human parasites in China. Zhonghua Yixue Zazhi 59:286–290, In Li et al. (2010)Google Scholar
  84. Yfanti G, Andreadis E, Spiliadou C, Diamantopoulos EJ (1996) A woman with fever and jejunal stricture. Lancet 347:802PubMedCrossRefGoogle Scholar
  85. Zlatkovic M, Stankovic I, Sarjanovic L (1998) Capillaria hepatica in a twenty month old child. In Schmidt (2001)Google Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hans-Peter Fuehrer
    • 1
    • 2
  • Petra Igel
    • 2
    • 3
  • Herbert Auer
    • 1
    Email author
  1. 1.Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and ImmunologyMedical University of ViennaViennaAustria
  2. 2.MARIB, Malaria Research Initiative BandarbanBandarbanBangladesh
  3. 3.Department of Pathobiology, Institute of ParasitologyUniversity of Veterinary Medicine ViennaViennaAustria

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