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Parasitology Research

, Volume 109, Issue 6, pp 1653–1659 | Cite as

Efficacy of sulfonamides and Baycox® against Isospora suis in experimental infections of suckling piglets

  • Anja JoachimEmail author
  • Hans-Christian Mundt
Original Paper

Abstract

Sulfonamide treatment of piglets against neonatal coccidiosis has frequently been suggested in the literature. In order to evaluate the efficacy of sulfonamides against experimental Isospora suis infections in suckling piglets (oral infection with 1,500 sporulated oocysts of I. suis per piglet on the fourth day of life), two trials were conducted. In trial I, oral sulfadimidine (group Sulfa-Oral) was applied in doses of 100 mg/kg of body weight (BW) 1 day before infection and 75 mg/kg BW daily for the following 5 days, and sulfamethoxypyrimidine (SMP) was applied parenterally in daily doses of 75 mg/kg BW for the same time period. In trial II, SMP was applied parenterally in doses of 75 mg/kg BW (a) from the day of infection daily for 7 days (SMP-Standard), (b) for 2 days starting on the day of infection (SMP-Early), (c) for 3 days starting 2 days post-infection (d.p.i.; SMP-Middle), (d) for 2 days starting 5 d.p.i. (SMP-Late), and (e) every other day from the day of infection until 6 d.p.i. (SMP-Alternating), as well as (f) orally in doses of 75 mg/kg BW from the day of infection for 7 days (SMP-Oral). The sulfonamide-treated groups were compared to a toltrazuril-treated group (single oral treatment with Baycox® 5% suspension, 20 mg/kg BW 2 d.p.i.) and to a water-treated Control group. Each group consisted of seven to nine piglets. The parameters evaluated were oocyst excretion and fecal consistency/diarrhea from 4 to 15 d.p.i. Sulfa-Oral, SMP-Early, and SMP-Late had no significant effect in reduction of oocyst excretion and diarrhea, whereas treatment for 3–7 days with SMP reduced both parasite shedding and diarrhea significantly. Oral treatment with SMP was comparable to parenteral application. Baycox® in a single application had the most pronounced effect and completely suppressed oocyst excretion and diarrhea during the examination period. It could be shown that repeated application of sulfonamides, provided that the appropriate time period after infection is covered, can in principle be used to control piglet coccidiosis; however, the amount of work required is considerable, and the practicability is poor. Due to the short half-life of sulfonamides in pigs and the lack of predictability of the time point of infection, an efficient application of sulfonamides to control piglet coccidiosis under field conditions appears unlikely. Baycox®, on the other hand, applied once during the prepatent period of infection, had a lasting effect and can be used to most effectively control I. suis.

Keywords

Coccidiosis Prepatent Period Sulfamethazine Toltrazuril Sporulated Oocyst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Berger H, Maddock HM, Gale GO, Simkins KL (1985) Evaluation of chlortetracycline-sulfamethazine combinations against experimental coccidiosis in swine. Agri-Practice 6:19–22Google Scholar
  2. Chapman HD (1989) Chemotherapy of caecal coccidiosis: efficacy of toltrazuril, sulphaquinoxaline/pyrimethamine and amprolium/ethopabate, given in drinking water, against field isolates of Eimeria tenella. Res Vet Sci 46:419–420PubMedGoogle Scholar
  3. Chapman HD (2009) A landmark contribution to poultry science—prophylactic control of coccidiosis in poultry. Poult Sci 4:813–815CrossRefGoogle Scholar
  4. Cunningham JM (1984) The field diagnosis and cost-effective treatment of swine coccidiosis. Agri-Practice 5:57–60Google Scholar
  5. Current WL (1987) Neonatal swine coccidiosis. Anim Health Nutr 42:8–10Google Scholar
  6. Daugschies A, Bialek R, Joachim A, Mundt HC (2001) Autofluorescence microscopy for detection of nematode eggs and protozoa, in particular Isospora suis, in swine feces. Parasitol Res 87:409–412PubMedCrossRefGoogle Scholar
  7. Driesen SJ, Fahy VA, Carland PG (1995) The use of toltrazuril for the prevention of coccidiosis in piglets before weaning. Aust Vet J 72:139–141PubMedCrossRefGoogle Scholar
  8. Haberkorn A (1996) Chemotherapy of human and animal coccidioses: state and perspectives. Parasitol Res 82:193–199PubMedCrossRefGoogle Scholar
  9. Kimbita EN, Silayo RS, Mwega ED, Mtau AT, Mroso JB (2009) Studies on the Eimeria of goats at Magadu dairy farm Sua, Morogoro, Tanzania. Trop Anim Health Prod 41:1263–1265PubMedCrossRefGoogle Scholar
  10. Kroker R (2003) Pharmaka zur Behandlung und Verhütung bakterieller Infektionen. In: Löscher W, Ungemach FR, Kroker R (eds) Pharmakotherapie bei Haus- und Nutztieren, 6th edn. Paul Parey, Berlin, pp 208–247Google Scholar
  11. Larsen K (1996) Isospora suis. Porcine neonatal coccidiosis. Dansk Veterinærtidskrift 79:387–392Google Scholar
  12. Lindsay DS, Stuart BP, Wheat BE, Ernst JV (1980) Endogenous development of the swine coccidium, Isospora suis Biester 1934. J Parasitol 66:771–779PubMedCrossRefGoogle Scholar
  13. Madsen P, Henriksen SA, Larsen K (1994) Prophylactic treatment of Isospora suis coccidiosis in piglets with toltrazuril in a special oral suspension. Proceedings of the 13th IPVS Congress, Bangkok, Thailand, p 256Google Scholar
  14. Martineau GP, Ménard J, Carabin H, Villeneuve A, Dumas G (1994) Strategic control of porcine coccidiosis with toltrazuril. Proceedings of the 13th IPVS Congress, Bangkok, Thailand, p 243Google Scholar
  15. Meyer C, Joachim A, Daugschies A (1999) Occurrence of Isospora suis in larger piglet production units and on specialized piglet rearing farms. Vet Parasitol 82:277–284PubMedCrossRefGoogle Scholar
  16. Mundt HC (2000) Baycox® 5%: an anticoccidial for the treatment of Isospora suis coccidiosis in piglets. Proceedings of the 16th IPVS Congress, Melbourne, AustraliaGoogle Scholar
  17. Mundt HC, Haberkorn A (1990) Porcine coccidiosis: a significant problem? Proceedings of the 11th IPVS Congress, Lausanne, Switzerland, p 325Google Scholar
  18. Mundt HC, Joachim A, Becka M, Daugschies A (2006) Isospora suis: an experimental model for mammalian intestinal coccidiosis. Parasitol Res 98:167–175PubMedCrossRefGoogle Scholar
  19. Mundt HC, Mundt-Wüstenberg S, Daugschies A, Joachim A (2007) Efficacy of various anticoccidials against experimental porcine neonatal isosporosis. Parasitol Res 100:401–411PubMedCrossRefGoogle Scholar
  20. Onawunmi OA, Todd AC (1976) Suppression and control of experimentally induced porcine coccidiosis with chlortetracycline combination, buquinolate, and lincomycin hydrochloride. Am J Vet Res 37:657–660PubMedGoogle Scholar
  21. Redrobe SP, Gakos G, Elliot SC, Saunders R, Martin S, Morgan ER (2010) Comparison of toltrazuril and sulphadimethoxine in the treatment of intestinal coccidiosis in pet rabbits. Vet Rec 21:287–290CrossRefGoogle Scholar
  22. Roberts L (1980) Coccidial infection in diarrhea of unweaned piglets. Proceedings of the 6th IPVS Congress, Copenhagen, Denmark, p 278Google Scholar
  23. Ruzicka CW, Andrews JJ (1984) Porcine neonatal coccidiosis—a clinical review. Iowa State Univ Vet 45:90–95Google Scholar
  24. Sanford SE, Josephson GKA (1981) Porcine neonatal coccidiosis. Can Vet J 22:282–285PubMedGoogle Scholar
  25. Scala A, Demontis F, Varcasia A, Pipia AP, Poglayen G, Ferrari N, Genchi M (2009) Toltrazuril and sulphonamide treatment against naturally Isospora suis infected suckling piglets: is there an actual profit? Vet Parasitol 163:362–365PubMedCrossRefGoogle Scholar
  26. Svensson C, Olofsson H (1996) Eimeria alabamensis coccidiosis in grazing calves: control by a long-acting baquiloprim/sulphadimidine bolus. Appl Parasitol 37:168–176PubMedGoogle Scholar
  27. Tubbs RC (1987) Controlling coccidiosis in neonatal pigs. Vet Med 82:646–650Google Scholar
  28. Vítovec J, Koudela B (1990) Double alteration of the small intestine in conventional and gnotobiotic piglets experimentally infected with the coccidium Isospora suis (Apicomplexa, Eimeriidae). Folia Parasitol (Praha) 37:21–33Google Scholar
  29. Worliczek H, Joachim A (2011) Neonatal porcine coccidiosis. Parasitol Res (in press)Google Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Institute of Parasitology, Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria
  2. 2.Bayer Animal Health GmbH, Clinical R & D ParasiticidesLeverkusenGermany

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