Parasitology Research

, Volume 105, Issue 4, pp 1169–1171 | Cite as

Plasmodium falciparum and Plasmodium vivax: so similar, yet very different

  • Aparup Das
  • Meenu Sharma
  • Bhavna Gupta
  • Aditya Prasad Dash
Short Communication


The recently published whole genome sequence information of one of the human malaria parasites, Plasmodium vivax, have provided opportunities to compare similar features with Plasmodium falciparum that causes the most deadly form of human malaria. We herewith present comparative genomic insights into the whole genome of the two parasites and also to several other characteristics in terms of disease pathogenecity, evolution, etc. We show that while high similarities exist at the functional gene level, several contrasting features for other characteristics are hallmarks of these two human malaria parasites.


Malaria Plasmodium Falciparum Cerebral Malaria Genome Sequence Information Human Malaria Parasite 
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We thank all members of the Evolutionary Genomics and Bioinformatics Laboratory for valuable suggestions and discussions and the Indian Council of Medical Research, New Delhi for intramural financial support.


  1. Bull PC, Buckee CO, Kyes S, Kortok MM, Thathy V, Guyah B, Stoute JA, Newbold CI, Marsh K (2008) Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks. Mol Microbiol 68:1519–1534PubMedCrossRefGoogle Scholar
  2. Carlton JM, Anguoli SV, Suh BB, Kooij TW, Pertea M, Silva JC, Ermolaeva MD, Allen EJ, Selengut JD, Koo HL et al (2002) Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature 419:512–519PubMedCrossRefGoogle Scholar
  3. Carlton J, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EM, Amedeo P et al (2008) Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 455:757–763PubMedCrossRefGoogle Scholar
  4. Das A, Bajaj R, Mohanty S, Swain V (2007) Genetic diversity and evolutionary history of Plasmodium falciparum and P. vivax. Curr Sci 92:1516–1524Google Scholar
  5. Deutsch M, Long M (1999) Intron–exon structures of eukaryotic model organism. Nucleic Acids Res 27:3219–3228PubMedCrossRefGoogle Scholar
  6. Duret L, Semon M, Piganeau G, Mouchiroud D, Galtier N (2002) Vanishing GC-rich isochores in mammalian genomes. Genetics 162:1837–1847PubMedGoogle Scholar
  7. Feng X, Carlton JM, Joy DA, Mu J, Tetsuya F, Bernard BS, Wang Y, Barnwell JW, Su X (2003) Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax. Proc Natl Acad Sci U S A 100:8502–8507PubMedCrossRefGoogle Scholar
  8. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S et al (2002) Genome sequence of human malaria parasite Plasmodium falciparum. Nature 419:498–511PubMedCrossRefGoogle Scholar
  9. Jongwutiwes S, Putaporntip C, Iwasaki T, Ferreira MU, Kanabara H, Hughes AL (2005) Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax. Mol Biol Evol 22:1733–1739PubMedCrossRefGoogle Scholar
  10. Mikkelsen TS, Hillier LDW, Eichler EE, Zody MC, Jaffe DB, Yang SP, Enard W, Hellmann I, Lindblad-Toh K, Altheide TK et al (2005) Initial sequences of the chimpanzee genome and comparison with the human genome. Nature 437:69–87CrossRefGoogle Scholar
  11. Sattabongkot J, Tsuboi T, Zollner GE, Sirichaisinthop J, Cui L (2004) Plasmodium vivax transmission: chances for control? Trends Parasitol 20:192–198PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Aparup Das
    • 1
  • Meenu Sharma
    • 1
  • Bhavna Gupta
    • 1
  • Aditya Prasad Dash
    • 1
  1. 1.Evolutionary Genomics and Bioinformatics LaboratoryNational Institute of Malaria ResearchNew DelhiIndia

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