Plasmodium falciparum and Plasmodium vivax: so similar, yet very different
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The recently published whole genome sequence information of one of the human malaria parasites, Plasmodium vivax, have provided opportunities to compare similar features with Plasmodium falciparum that causes the most deadly form of human malaria. We herewith present comparative genomic insights into the whole genome of the two parasites and also to several other characteristics in terms of disease pathogenecity, evolution, etc. We show that while high similarities exist at the functional gene level, several contrasting features for other characteristics are hallmarks of these two human malaria parasites.
We thank all members of the Evolutionary Genomics and Bioinformatics Laboratory for valuable suggestions and discussions and the Indian Council of Medical Research, New Delhi for intramural financial support.
- Das A, Bajaj R, Mohanty S, Swain V (2007) Genetic diversity and evolutionary history of Plasmodium falciparum and P. vivax. Curr Sci 92:1516–1524Google Scholar