Efficacy and Safety of Emodepside 2.1 %/Praziquantel 8.6% Spot-on Formulation in the Treatment of Feline Aelurostrongylosis
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The objective of the present study was to evaluate the efficacy and safety of the antiparasitic spot-on formulation containing emodepside 2.1 %/praziquantel 8.6% (Profender®, Bayer) in the treatment of natural feline infection with the lungworm Aelurostrongylus abstrusus (Nematoda, Strongylida). Efficacy of Profender® given once at the licensed dose was tested in comparison to a control oral formulation containing fenbendazole 18.75 % (Panacur®, Intervet) given over three consecutive days at the licensed dose. Efficacy assessment was based on larvae per gramme of faeces (LPG) counts, measured on days 28 ± 2 following treatment and compared to counts on days –6 to –2. In total 24 cats treated either with Profender® (n = 12) or with Panacur (n = 12) were included in the assessment of efficacy and safety. Mean LPG post-baseline counts (days 28 ± 2) were 1.3 LPG for both Profender® and Panacur®, demonstrating similar efficacy of 99.38 % for Profender® and 99.29 % for the control product. No treated animals showed adverse events. This trial demonstrated that both Profender® spot-on formulation and oral paste Panacur® are safe and effective in the treatment of aelurotrongylosis in cats. Future practical perspectives in feline medicine and the major advantages of the spot-on product compared to the oral paste are discussed.
KeywordsIvermectin Praziquantel Macrocyclic Lactone Moxidectin Emodepside
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