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Parasitology Research

, 105:593 | Cite as

Enzymatic antioxidant systems in helminth parasites

  • Lorena Chiumiento
  • Fabrizio BruschiEmail author
Review

Abstract

Parasitic helminths have a coexistence with mammalian hosts whereby they survive for several years in known hostile conditions of their hosts. Many explanations exist describing how these parasitic helminths are able to survive. In the last years, a lot of studies have focused on both enzymatic and non-enzymatic antioxidant systems now shown to exist in these parasites and which may serve as defence tactics against the host-generated oxygen radicals. The relevance of antioxidant enzymes is confirmed by the fact that some of these molecules represent putative protective anti-parasite vaccines (i.e. in schistosomiasis). This review tries to compile what is known to date of the enzymatic antioxidant systems in selected parasitic helminths.

Keywords

Reactive Oxygen Species Adult Worm Schistosoma Artemether Echinococcus Granulosus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ROS

Reactive oxygen species

UV

Ultraviolet light

NO

Nitric oxide

O2

Molecular oxygen

H2O2

Hydrogen peroxide

SOD

Superoxide dismutase

CAT

Catalase

GPx

Glutathione peroxidase

NADPH

Nicotinamide adenine dinucleotide phosphate, reduced form

Prx

Peroxiredoxins

Cys

Cysteine

TRX

Thioredoxins

GSH

Glutathione

GSTs

Glutathione-S-transferases

TRXPx

Thioredoxin peroxidase

CT-SOD

Cytosolic superoxide dismutase

SP-SOD

Extracellular or with peptide signal superoxide dismutase

SmGST

Schistosoma mansoni GST

SmGSTO

S. mansoni ω class GST

Sm28GST

28 kDa GST of Schistosoma mansoni

OvTPx

TRXPx of O. volvulus

TsGST24

GST of 24 kDa of T. spiralis

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© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Experimental Pathology, M.B.I.E.Università di PisaPisaItaly

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