Parasitology Research

, 105:593 | Cite as

Enzymatic antioxidant systems in helminth parasites

  • Lorena Chiumiento
  • Fabrizio BruschiEmail author


Parasitic helminths have a coexistence with mammalian hosts whereby they survive for several years in known hostile conditions of their hosts. Many explanations exist describing how these parasitic helminths are able to survive. In the last years, a lot of studies have focused on both enzymatic and non-enzymatic antioxidant systems now shown to exist in these parasites and which may serve as defence tactics against the host-generated oxygen radicals. The relevance of antioxidant enzymes is confirmed by the fact that some of these molecules represent putative protective anti-parasite vaccines (i.e. in schistosomiasis). This review tries to compile what is known to date of the enzymatic antioxidant systems in selected parasitic helminths.


Reactive Oxygen Species Adult Worm Schistosoma Artemether Echinococcus Granulosus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Reactive oxygen species


Ultraviolet light


Nitric oxide


Molecular oxygen


Hydrogen peroxide


Superoxide dismutase




Glutathione peroxidase


Nicotinamide adenine dinucleotide phosphate, reduced form












Thioredoxin peroxidase


Cytosolic superoxide dismutase


Extracellular or with peptide signal superoxide dismutase


Schistosoma mansoni GST


S. mansoni ω class GST


28 kDa GST of Schistosoma mansoni


TRXPx of O. volvulus


GST of 24 kDa of T. spiralis


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© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Experimental Pathology, M.B.I.E.Università di PisaPisaItaly

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