An update on the use of helminths to treat Crohn’s and other autoimmunune diseases
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This review updates our previous one (Reddy and Fried, Parasitol Research 100: 921–927, 2007) on Crohn’s disease and helminths. The review considers the most recent literature on Trichuris suis therapy and Crohn’s and the significant literature on the use of Necator americanus larvae to treat Crohn’s and other autoimmune disorders. The pros and cons of helminth therapy as related to autoimmune disorders are discussed in the review. We also discuss the relationship of the bacterium Campylobacter jejuni and T. suis in Crohn’s disease. The significant literature on helminths other than N. americanus and T. suis as related to autoimmune diseases is also reviewed.
KeywordsMultiple Sclerosis Multiple Sclerosis Patient Primary Biliary Cirrhosis Ivermectin Helminth Infection
- Bee RJ (1976) The relationship between Trichuris trichiura (Linnaeus 1758) of man and Trichuris suis (Schrank 1788) of the pig. Res Vet Sci 20:47–54Google Scholar
- Mansfield LS, Gauthier DT, Abner SA, Jones KM, Wilder SR, Urban JF (2003) Enhancement of disease and pathology by synergy of Trichuris suis and Campylobacter jejuni in the colon of immunologically naïve swine. Am J Trop Med Hyg 68:70–80Google Scholar
- Svoboda E (2006) Scientist at work: David Pritchard, The worms crawl in—New York Times article http://www.nytimes.com/2008/07/01/health/research/01prof.html?_r=2&pagewanted=1&sq&st=nyt&scp=2&oref=slogin
- Velasquez-Manoff V (2008) Trichuris suis ova whipworm and Necator americanus hookworm therapy for Crohn's disease-New York Times article http://www.nytimes.com/2008/06/29/magazine/29wwin-essay-t.html?_r=1&r...