Parasitology Research

, Volume 102, Issue 3, pp 547–550 | Cite as

Plasmodium malariae infection in spite of previous anti-malarial medication

  • Irmela Müller-Stöver
  • Jaco J. Verweij
  • Barbara Hoppenheit
  • Klaus Göbels
  • Dieter Häussinger
  • Joachim Richter
Short Communication

Abstract

Plasmodium malariae is regarded as usually being susceptible to all anti-malarials whether applied for prophylaxis or treatment. We report on three cases of P. malariae infection which occurred 12–14 weeks after anti-malarial chemoprophylaxis or treatment with mefloquine or atovaquone/proguanil. The most likely explanation for the failure of mefloquine and atovaquone/proguanil to prevent quartan malaria occurring some months later is the insufficient effect on the particularly long-lasting pre-erythrocytic development stages of P. malariae.

Notes

Acknowledgements

We wish to thank Ebenezer Adusu, Institute of Tropical Medicine and International Health Berlin, for double reading of the stained blood films.

Conflicts of interest statement

The authors have no conflicts of interest concerning the work reported in this paper.

References

  1. Adegnika AA, Verweij JJ, Agnandji ST, Chai SK, Breitling LP, Ramharter M, Frolich M, Issifou S, Kremsner PM, Yazdanbakhsh M (2006) Microscopic and sub-microscopic Plasmodium falciparum infection, but not inflammation caused by infection, is associated with low birth weight. Am J Trop Med Hyg 75:798–803PubMedGoogle Scholar
  2. Baas MC, Wetsteyn JCFM, van Gool T (2006) Patterns of imported malaria at the Academic Medical Center, Amsterdam, the Netherlands. J Travel Med 13:2–7PubMedCrossRefGoogle Scholar
  3. Gilles HM, Warrel DA (1993) Bruce-Chwatts essential malariology, 3rd edn. Arnold, London, p 340Google Scholar
  4. Grobusch MP, Göbels K, Teichmann D (2004) Is quartan malaria safely prevented by mefloquine prophylaxis? J Travel Med 11:125–126PubMedCrossRefGoogle Scholar
  5. Hess FJ, Kilian AD, Nothdurft HD, Löscher T (1993) Problems in the therapy of mixed malarial infection: a case of infection with Plasmodium falciparum and P. malariae treated with mefloquine and halofantrine. Trans R Soc Trop Med Hyg 87:688PubMedCrossRefGoogle Scholar
  6. Hogh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Gunther M, Joubert I, Kain KC, Shaw D, Roskell NS, Chulay JD (2000) Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Lancet 356:1888–1894PubMedCrossRefGoogle Scholar
  7. Maguire JD, Sumawinata IW, Masbar S, Laksana B, Prodjodipuro P, Susanti I, Sismadi P, Mahmud N, Bangs MJ, Baird JK (2002) Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. Lancet 360:58–60PubMedCrossRefGoogle Scholar
  8. Mehlhorn H, Eichenlaub D, Löscher T, Peters W (1995) Diagnostik und Therapie der Parasitosen des Menschen. Gustav Fischer, Stuttgart, p 134Google Scholar
  9. Niesters HG (2002) Clinical virology in real time. J Clin Virol 25(Suppl 3):S3–S12PubMedCrossRefGoogle Scholar
  10. Radloff PD, Philipps J, Hutchinson D, Kremsner PG (1996) Atovaquone plus proguanil is an effective treatment for Plasmodium ovale and P. malariae malaria. Trans R Soc Trop Med Hyg 90:682PubMedCrossRefGoogle Scholar
  11. Srivastava IK, Morrisey JM, Darrouzet E, Daldal F, Vaidya AB (1999) Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. Mol Microbiol 33:704–711PubMedCrossRefGoogle Scholar
  12. White NJ (2002) Malaria. In: Cook GC, Zumla A (eds) Manson’s tropical diseases, 21st edn. Saunders, Philadelphia, pp 1205–1295Google Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Irmela Müller-Stöver
    • 1
  • Jaco J. Verweij
    • 2
  • Barbara Hoppenheit
    • 1
  • Klaus Göbels
    • 1
  • Dieter Häussinger
    • 1
  • Joachim Richter
    • 1
  1. 1.Tropenmedizinische Ambulanz, Klinik für Gastroenterologie, Hepatologie und InfektiologieUniversitätsklinikum DüsseldorfDüsseldorfGermany
  2. 2.Department of Parasitology, Department of Medical MicrobiologyLeiden University Medical CenterLeidenThe Netherlands

Personalised recommendations