Parasitology Research

, 102:357

Identification of an eosinophil chemotactic factor from anopheline mosquitoes as a chitinase family protein

  • Makoto Owhashi
  • Masakazu Harada
  • Setsuo Suguri
  • Hiroshi Omae
  • Akira Ishii
Original Paper

DOI: 10.1007/s00436-007-0769-3

Cite this article as:
Owhashi, M., Harada, M., Suguri, S. et al. Parasitol Res (2008) 102: 357. doi:10.1007/s00436-007-0769-3

Abstract

Anopheline mosquitoes play an essential role in malaria transmission. The mosquito salivates copiously when probing for the location of a blood vessel. We found that the saliva of anopheline mosquitoes has chemotactic activity for naive eosinophils or neutrophils. The major eosinophil chemotactic component in saliva was shown to be one of the chitinase family proteins. A similar chitinase family protein was found also in the midgut of the anopheline mosquito. Production of antibodies to the chitinase family protein was generally observed in the sera of residents of a malaria endemic area. Both Plasmodium falciparum-infected and uninfected individuals had antibodies to chitinases. These results suggest that the chitinase family protein in mosquito saliva contributes to eliciting an inflammatory response of eosinophils in the host skin followed by antibody production in the host.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Makoto Owhashi
    • 1
  • Masakazu Harada
    • 2
  • Setsuo Suguri
    • 2
  • Hiroshi Omae
    • 3
  • Akira Ishii
    • 4
  1. 1.Faculty of Integrated Arts and SciencesTokushima UniversityTokushimaJapan
  2. 2.Department of Medical ZoologyKagawa UniversityMikiJapan
  3. 3.Department of ParasitologyNational Institute of Infectious DiseaseTokyoJapan
  4. 4.Department of Public HealthJissen Women’s UniversityHinoJapan

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