Leishmania major infection in a patient with visceral leishmaniasis: treatment with Amphotericin B
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We have reported an acute form of visceral leishmaniasis, which was caused by Leishmania major, in Southern Iran. The parasite was isolated from a 30-year-old man living in Bushehr Province, Southern Iran, and an endemic region of kala-azar in south of Iran. The patient had typical clinical signs of Mediterranean kala-azar, and besides parasitological, biochemical, and immunological findings confirming diagnosis of visceral leishmaniasis, the agent was identified as L. major using Nested polymerase chain reaction. The patient was treated successfully with Amphotericin B during a 1-month period.
KeywordsVisceral Leishmaniasis Leishmaniasis Inguinal Lymph Node Cutaneous Leishmaniasis Leishmania Species
The authors would like to thank the Office of Vice Chancellor for Research of Shiraz University of Medical Sciences for financial support and the Center for Development of Clinical Studies of Nemazee Hospital for typing assistance.
- Garcia-Cordoba F, Ortuño FJ, Segovia M, Gonzalez Diaz G (2005) Fatal visceral leishmaniasis, with massive bone-marrow infection, in an immunosuppressed but HIV-negative Spanish patient, after the initiation of treatment with meglumine antimoniate. Ann Trop Med Parasitol 99:125–130PubMedCrossRefGoogle Scholar
- Mehrabani D, Motazedian M, Oryan A, Hatam GR, Asgari G, Karamian M (2007) Microscopical and PCR-based detection and identification of Leishmania major in Tatera indica and rodents of the genus Gerbillus in search of its reservoir in the Larestan region, Fars Province, Southern Iran. Ann Trop Med Parasitol 100:1–8Google Scholar
- Noyes HA, Reyburn H, Bailey JW, Smith D (1998) A nested-PCR-based schizodeme method for identifying Leishmania kinetoplast minicircle classes directly from clinical samples and its application to the study of the epidemiology of Leishmania tropica in Pakistan. J Clin Microbiol 36:2877–2881PubMedGoogle Scholar