Parasitology Research

, Volume 101, Issue 5, pp 1319–1322

Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs

  • R. Hadighi
  • P. Boucher
  • A. Khamesipour
  • A. R. Meamar
  • G. Roy
  • M. Ouellette
  • M. Mohebali
Original Paper

DOI: 10.1007/s00436-007-0638-0

Cite this article as:
Hadighi, R., Boucher, P., Khamesipour, A. et al. Parasitol Res (2007) 101: 1319. doi:10.1007/s00436-007-0638-0

Abstract

Cutaneous leishmaniasis (CL) is a major health problem in endemic areas of Iran. The pentavalent antimony (SbV) based drug Glucantime is the first line of treatment for CL in Iran, but recently SbV-resistant Leishmania tropica isolates derived from unresponsive patients were reported. We show in this study that these resistant parasites are cross-resistant to the other SbV-containing drug Pentostam and at least for one isolate also to amphotericin B. However, these resistant isolates were shown to be sensitive to miltefosine and paromomycin. The latter two drugs could thus be useful alternatives for the treatment of leishmaniasis in Iran even for SbV-resistant isolates.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • R. Hadighi
    • 1
  • P. Boucher
    • 2
  • A. Khamesipour
    • 3
  • A. R. Meamar
    • 1
  • G. Roy
    • 2
  • M. Ouellette
    • 2
  • M. Mohebali
    • 4
  1. 1.Department of Parasitology, Faculty of MedicineIran University of Medical SciencesTehranIran
  2. 2.Centre de Recherche en Infectiologie and Département de Biologie MédicaleUniversité LavalQuébecCanada
  3. 3.Center for Research and Training in Skin Diseases and LeprosyTehran University of Medical SciencesTehranIran
  4. 4.School of Public Health and Institute of Public Health ResearchTehran University of Medical SciencesTehranIran

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