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Parasitology Research

, Volume 100, Issue 6, pp 1261–1266 | Cite as

CD4+, CD8+, immunoglobulin status and ocular lesions among some onchocerciasis-infected rural Nigerians

  • O. P. G. Nmorsi
  • N. C. D. Ukwandu
  • O. J. Alabi-Eric
  • W. Popoola
  • M. Osita-Emina
Original Paper

Abstract

CD4+, CD8+, immunoglobulin status and ocular lesions of some onchocerciasis-infected rural Nigerians as manifested by the presence of microfilariae in their skin snips and some chronic symptoms of the parasitic infestation were evaluated. The highest mean CD4+ and mean microfilarial (mff) load of 560 ± 20.46 unit cells/μl and 20 mff/mg were recorded among the individuals within the second decade of life, while the least mean CD4+ and mff load of 307.20 ± 11.23 unit cell/μl and 6.5 mff/mg occurred among volunteers after 60 years of age. The highest mean CD8+ of 388.00 ± 23.71 unit cells/μl occurred at the third decade of life. The individuals above 60 years had the least mean CD8+ of 350.25 ± 11.90 unit cells/μl. The volunteers had mean CD4+ of 372.45 ± 109.02 unit cells/μl and mean CD8+ of 359.42 ± with an overall CD4+:CD8+ ratio of 1.04. The mean CD4+ and mean CD8+ had positive correlation with the mean microfilarial load (r = 0.52 and r = 0.40), respectively. The mean IgE, IgG, lgA, IgM, and IgD were 2,074.82 ± 823.09, 19.36 ± 2.49, 3.88 ± 0.26, 3.59 ± 0.38, and 0.29 ± 0.19 mg/dl, and these immunoglobulins negatively correlated with the mean microfilarial load at r = −0.02, r = −0.15, r = −0.82, r = −0.37, and r = 0.26, respectively. Among these immunoglobulins evaluated, only mean IgE (2,074.82 ± 823 ng/ml) was statistically different from the control subjects (0 mg/dl) at t = 3.39, P < 0.05. In all, the prevalence of the visual impairment and lesions were low. Among the six visual lesions, namely, cataract, choroidoretinitis, iridocyclitis, glaucoma, sclerosing keratitis, and optic atrophy encountered in Egoro-Eguare, only optic atrophy and sclerosing keratitis was reported among the children. The female adults had the highest prevalence of reduced vision 20(43.5%). Also, the prevalence of choroidoretinitis (2.2%) and iridocyclitis (2.2%) were the least prevalent ocular lesions reported among these female adults. The depletion of the CD4+ contributed to the low prevalence of visual impairment and lesions in this locality. The depleted CD4+, CD8+, and the lower values of IgA, IgM, and IgG contributed in the maintenance of chronicity of onchocerciasis in Egoro-Eguare, Nigeria.

Keywords

Glaucoma Visual Impairment Ivermectin Optic Atrophy Onchocerciasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Berghout E (1973) Onchocerciasis and glaucoma in the forest area of Ghana. Trop Geogr Med 25:233–237PubMedGoogle Scholar
  2. Edungbola LD, Asaolu SO (1984) Parasitologic survey of onchocerciasis (River blindness) in Babana District Kwara State, Nigeria. Am J Trop Med Hyg 33:1147–1154 PubMedGoogle Scholar
  3. Edungbola LD, Alabi TO, Oni GA, Asaolu SO, Ogbubanjo BO, Parakoyi BD (1987) Leopard skin as a rapid diagnostic index for estimating the endemicity of African onchocerciasis. Int J Epidemiol 16:590–594PubMedCrossRefGoogle Scholar
  4. Hall LR, Jussuf TK, Diaconu E, Pearman E (2000) CD4+ Depletion selectively inhibits eosinophil resentment to the cornea and abrogates Onchocerca volvulus keratitis (River blindness). Infect Immun 88(9):5459–5461CrossRefGoogle Scholar
  5. Haslett C, Chilvers ER, Boon NA, Collerdge NR (2002) Principles and practice of medicine, 19th edn. Churchill Livingstone, p 1272Google Scholar
  6. Kuby J (1997) Immunology, 3rd edn. W.H. Freeman, p 664Google Scholar
  7. Mancini G, Carbonara AO, Hermans JPC (1965) Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2:235–259PubMedCrossRefGoogle Scholar
  8. Mckechnie N, Braun G, Connor V, Klager S, Taylor D, Alexander RS, Gilbert C (1993) Immunologic cross-reactivity in the pathogenesis of ocular onchocerciasis. Investig Ophthalmol Vis Sci 38:2888–2902Google Scholar
  9. Mckechnie NM, Gurr W, Braun G (1997) Immunization with the cross-reactive antigens OV39 from Onchocerca volvulus and the hr 44 from human retinal tissue induces ocular pathology and activates retinal microglia. J Infect Dis 176:1334–1343PubMedCrossRefGoogle Scholar
  10. Nmorsi OPG, Kio FE (1994) Hypoendemicity of onchocerciasis in a Odiguetue. Ovia North East Local Government Area, Edo State, Nigeria. J Med Lab Sci 4:21–25Google Scholar
  11. Nmorsi P, Obiamiwe BA (1992) Onchocerciasis in Imeri Ondo State, Nigeria. Nigerian J Parasitol 13:43–49Google Scholar
  12. Nmorsi OPG, Oladokun IAA, Egwunyenga OA, Oseha E (2002) Eye lesions and onchocerciasis in a rural farm settlement in Delta State, Nigeria South East Asian. J Trop Med Public Health 33(1):28–32Google Scholar
  13. Nwaorgu OC, Okeibunor JC (1999) Onchocerciasis in pre-primary school children in Nigeria. Lessons for onchocerciasis country control programme. Acta Trop 73:211–212PubMedCrossRefGoogle Scholar
  14. Plaiser AP, van Oortmarssen G-J, Remme J, Habbema JD (1991) The reproductive lifespan of Onchocerca volvulus in West African savannah. Acta Trop 48:271–284CrossRefGoogle Scholar
  15. Soboslay PT, Dreweck CM, Hoffmann WH, Luder CG, Heuschkel C, Eorgen H, Banla M, Schulz-key H (1992) Ivermectin-facilitated immunity onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment. Clin Exp Immunol 89(3):407–413PubMedCrossRefGoogle Scholar
  16. Stilma JS, Ebidy DM, Coker SM (1983) Eye screening in 2234 Sierra Leonean schoolchildren and detection of onchocerciasis. Docum Ophthalmol 53:123–129CrossRefGoogle Scholar
  17. Ufomadu GO, Akpa AUC, Ekejindu IM (1992) Human onchocerciasis in the lower Jos plateau central Nigeria: the prevalence, geographical distribution and epidemiology in Akwanga and Lafia local government areas. Ann Trop Med Parasitol 86:637–647PubMedGoogle Scholar
  18. Umeh RE (1999) The causes and profile of visual loss in an onchocerciasis-endemic Forest Savanna zone in Nigeria. Ophthalmic Epidemiol 6:303–315PubMedCrossRefGoogle Scholar
  19. World Health Organisation (1973) The Prevention of blindness. WHO Technical Report Series no 518. Geneva WHOGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • O. P. G. Nmorsi
    • 1
    • 4
  • N. C. D. Ukwandu
    • 2
  • O. J. Alabi-Eric
    • 1
  • W. Popoola
    • 1
  • M. Osita-Emina
    • 3
  1. 1.Tropical Diseases Research Centre, Department of ZoologyAmbrose Alli UniversityEkpomaNigeria
  2. 2.Department of Pathological Sciences, Faculty of Clinical SciencesAmbrose Alli UniversityEkpomaNigeria
  3. 3.Optomed Eye ClinicWarriNigeria
  4. 4.EkpomaNigeria

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