Parasitology Research

, Volume 96, Issue 3, pp 162–165 | Cite as

Efficacy of Amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to Chloroquine and Sulphadoxine/Pyrimethamine

  • Jens Graupner
  • Klaus GöbelsEmail author
  • Martin P. Grobusch
  • Anne Lund
  • Joachim Richter
  • Dieter Häussinger
Original Paper


Falciparum Malaria is hyperendemic in southern Nigeria and chloroquine resistance is an increasing problem. Therefore, the parasitological and haematological response to treatment with amodiaquine was studied in children under 5 years during a 14-day follow-up. Of 105 children who accomplished the study (out of 114 who were enrolled), 95.3% were parasite-negative on thick blood film on day 7, which decreased to 89.5% on day 14. The haemoglobin levels increased on average by 1.3% on day 14 (±1.9) and more pronounced in children with anaemia < 10 g/dl on enrolment. The number of patients with adverse events (mainly pruritus and nausea) was few. This study shows that amodiaquine is effective, safe and affordable in an area with high resistance to chloroquine.


Malaria Chloroquine Falciparum Malaria Halofantrine Amodiaquine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The results presented in this paper are part of a medical thesis by Jens Graupner


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Jens Graupner
    • 1
  • Klaus Göbels
    • 2
    Email author
  • Martin P. Grobusch
    • 3
  • Anne Lund
    • 1
  • Joachim Richter
    • 2
  • Dieter Häussinger
    • 2
  1. 1.Medecins sans Frontières (MSF)AmsterdamThe Netherlands
  2. 2.Tropenambulanz der Klinik für Gastroenterologie, Hepatologie und InfektiologieUniversitätsklinikum DüsseldorfDüsseldorfGermany
  3. 3.Institut für TropenmedizinErberhard-Karls Universität TübingenTübingenGermany

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