Parasitology Research

, Volume 95, Issue 6, pp 420–426 | Cite as

IgG isotype to C-terminal 19 kDa of Plasmodium vivax merozoite surface protein 1 among subjects with different levels of exposure to malaria in Brazil

  • Cristiane G. Morais
  • Irene S. Soares
  • Luzia H. Carvalho
  • Cor Jesus F. Fontes
  • Antoniana U. Krettli
  • Érika Martins Braga
Original Paper

Abstract

Subclasses of antibodies to the C-terminal 19 kDa fragment of the Plasmodium vivax merozoite surface protein 1 (PvMSP-119) were assessed among subjects with distinct degrees of malaria exposure in the Brazilian endemic area. The PvMSP-119 specific IgG1and IgG3 levels were low among subjects with long-term exposure (~19 years) when compared to subjects less and sporadically exposed (<1 year). No statistically difference was observed in IgG subclass distribution of antibodies from symptomatic Plasmodium-infected patients, asymptomatic parasite carriers and non-infected subjects living in a same mesoendemic area. Subjects briefly exposed to a P. vivax outbreak living in a rural community outside the endemic area were also evaluated to measure the persistence of specific antibodies. IgG anti-PvMSP-119 antibodies persisted in 40% of the subjects who had had malarial symptoms 8 months before and decreased after 7 years (28%). Specific IgG1 were the predominant isotype. Our study emphasizes the highly immunogenicity of the PvMSP-119 and points toward its possible use as a potential malaria vaccine.

Keywords

Malaria Malaria Transmission Vivax Malaria Malaria Vaccine Reactivity Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was financially supported by Fundação de Amparo à Pesquisa do Estado de Minas Gerais FAPEMIG (grant no. CBB2323/97). Informed consent was obtained from subjects according to the Universidade Federal de Minas Gerais Ethics Committee (15 April 1998) and Fundação Oswaldo Cruz Ethics Committee (26 November 1994).

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Cristiane G. Morais
    • 1
  • Irene S. Soares
    • 2
  • Luzia H. Carvalho
    • 3
  • Cor Jesus F. Fontes
    • 4
  • Antoniana U. Krettli
    • 1
    • 3
  • Érika Martins Braga
    • 1
  1. 1.Departamento de Parasitologia, Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Departamento de Análises Clínicas e ToxicológicasUniversidade de São PauloSao PauloBrazil
  3. 3.Centro de Pesquisas René Rachou/FIOCRUZBelo HorizonteBrazil
  4. 4.Departamento de Clínica MédicaUniversidade Federal de Mato GrossoCuiabaBrazil

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