Parasitology Research

, Volume 95, Issue 5, pp 333–338 | Cite as

Comparison of modulation of sheep, mouse and buffalo lymphocyte responses by Fasciola hepatica and Fasciola gigantica excretory-secretory products

  • W. Zhang
  • E. Moreau
  • F. Peigné
  • W. Huang
  • A. Chauvin
Original Paper


In order to explain the difference in susceptibility to Fasciola hepatica and F. gigantica between animal species, the activity of their excretory-secretory products (FhESP and FgESP, respectively) on concanavalin A (ConA)-induced proliferation of different animal species (sheep, mouse and buffalo) lymphocytes was compared. At high doses, FhESP inhibited proliferation of lymphocytes of all the animal species tested, and at low doses they inhibited the proliferation of sheep lymphocytes and increased the proliferation of buffalo and mouse lymphocytes. The effects of FgESP were similar but the intensity of FgESP inhibition was less than FhESP. The immunomodulatory effects of FhESP or FgESP could not alone explain the susceptibility level of hosts to Fasciola spp. The immunomodulatory molecules of FhESP and FgESP and their role in the course of Fasciola spp. infection should be further investigated.


Peripheral Blood Mononuclear Cell Fatty Acid Binding Protein Suboptimal Dose Hepatica Infection Peripheral Blood Mononuclear Cell Proliferation 
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This work was supported by Programme de Recherches Avancées (PRA B99-04) and National Natural Science Foundation of China (30260082).


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • W. Zhang
    • 1
    • 2
  • E. Moreau
    • 1
  • F. Peigné
    • 1
  • W. Huang
    • 2
  • A. Chauvin
    • 1
  1. 1.UMR INRA/ENVN Interactions Hôte-Parasite-MilieuEcole Nationale Vétérinaire de NantesNantes Cedex 03France
  2. 2.College of Animal Science and TechnologyGuangxi UniversityNanningChina

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