Parasitology Research

, Volume 93, Issue 4, pp 322–327

No change in parasite genotype during single episodes of Plasmodium falciparum malaria in Gabonese children

  • Michel A. Missinou
  • Jürgen F. J. Kun
  • Peter G. Kremsner
Original Paper

Abstract

Patients living in endemic areas can carry a mixture of Plasmodium falciparum genotypes. To investigate the genetic composition of parasite genotypes in malaria patients during the acute phase of the infection, we performed close follow-ups of 17 Gabonese pediatric patients aged 2–7 years. Capillary blood samples were taken on admission and every 4–6 h after the start of quinine therapy. Merozoite surface protein 2 (MSP2) genotypes were used to assess the parasites’ genetic characteristics in each sample. We found that each patient carried parasites with the same genotypic pattern throughout the infection.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Michel A. Missinou
    • 1
    • 2
  • Jürgen F. J. Kun
    • 1
  • Peter G. Kremsner
    • 1
    • 2
  1. 1.Department of Parasitology, Institute of Tropical MedicineUniversity of TübingenTübingenGermany
  2. 2.Medical Research UnitAlbert Schweitzer HospitalLambarénéGabon

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