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Parasitology Research

, Volume 88, Issue 12, pp 1051–1054 | Cite as

The molecular characteristics of circumsporozoite protein gene subtypes from Plasmodium vivax isolates in Republic of Korea

  • Tak Kim
  • Yoo Kim
  • Ki-Joon Song
  • Jin-Won Song
  • Sang Cha
  • Yong Kim
  • Young Shin
  • In Suh
  • Chae Lim
Original Paper

Abstract.

The circumsporozoite protein (CSP) of Plasmodium vivax has two sequence types, VK210 and VK247, each of which has a characteristic tandem amino acid repetition. Previous studies report that a resurgent Korean strain has unique amino acid sequences in tandem repeats and post-repeat areas compared to other strains of P. vivax. We have found another molecular subtype of the CSP gene from resurgent Korea isolates. New strains show a total of eighteen amino acid repeats and different amino acid repeat patterns compared with previous resurgent Korean isolates. In the post-repeat region, AGGNAANKKAEDAGGNA and three repeats of the sequence GGNA was found in all six isolates. These results of sequence comparison revealed that there are two types of isolates based on CSP in South Korea.

Keywords

Plasmodium Tandem Repeat Sequence Comparison Sequence Type Molecular Characteristic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Tak Kim
    • 1
  • Yoo Kim
    • 2
  • Ki-Joon Song
    • 3
  • Jin-Won Song
    • 3
  • Sang Cha
    • 4
  • Yong Kim
    • 5
  • Young Shin
    • 6
  • In Suh
    • 2
  • Chae Lim
    • 2
  1. 1.Department of Obstetrics and Gynecology, Korea University Ansan Hospital, 516, Gojan Dong, Ansan City, 425-707, Republic of Korea
  2. 2.Department of Clinical Pathology and Travel Medicine, Korea University Ansan Hospital, 516, Gojan Dong, Ansan City, 425-020, Republic of Korea
  3. 3.Department of Microbiology, College of Medicine, Korea University 126-1, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-705, Republic of Korea
  4. 4.Department of Diagnostic Radiology, Korea University Ansan Hospital, 516, Gojan Dong, Ansan City, 425-020, Republic of Korea
  5. 5.Department of Psychiatrics, Korea University Ansan Hospital, 516, Gojan Dong, Ansan City, 425-020, Republic of Korea
  6. 6.Division of Infectious Disease, Department of Pediatrics, Korea University Ansan Hospital, 516, Gojan Dong, Ansan City, 425-020, Republic of Korea

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