Research in Experimental Medicine

, Volume 197, Issue 6, pp 329–336

Liver bilirubin UDP-glucuronosyltransferase activity in chronic nonhemolytic unconjugated hyperbilirubinemia of adults

  • Akiharu Watanabe
  • Hiroyuki Wakabayashi
  • Yoshihiro Kuwabara
  • Hiroshi Yamamoto
  • Syuzou Hattori
  • Takao Tsuji
Article

Abstract

Ten adult patients with chronic nonhemolytic unconjugated (indirect) hyperbilirubinemia were analyzed by determining bilirubin uridine diphosphate-glucuronosyltransferase activity according to a more physiological and sensitive method (9 control cases, 0.457±0.163 nmole/mg protein/min). There was no overlap of the enzyme activities of 2 cases with Crigler-Najjar syndrome (type II) (0.006 nmole/mg protein/min on average) and 6 cases with Gilbert’s syndrome (0.051±0.016 nmole/mg protein/min). The enzyme activities in 2 patients with post-hepatitic hyperbilirubinemia were within the normal range. A new classification of nonhemolytic unconjugated hyperbilirubinemia in adults is proposed according to the results of this enzyme activity and the recent data on the gene mutation of this enzyme.

Key words

Bilirubin uridine diphosphate-glucuronosyltransferase Unconjugated hyperbilirubinemia Crigler-Najjar syndrome Gilbert’s syndrome 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Akiharu Watanabe
    • 1
  • Hiroyuki Wakabayashi
    • 1
  • Yoshihiro Kuwabara
    • 1
  • Hiroshi Yamamoto
    • 2
  • Syuzou Hattori
    • 2
  • Takao Tsuji
    • 2
  1. 1.Third Department of Internal Medicine, Faculty of MedicineToyama Medical and Pharmaceutical UniversitySugitani, Toyama 930-01Japan
  2. 2.First Department of Internal MedicineOkayama University Medical SchoolOkayamaJapan

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