Evaluation of microvessel density by computerised image analysis in human renal cell carcinoma

Correlation to pT category, nuclear grade, proliferative activity and occurrence of metastasis
  • Cordula Herbst
  • Hartwig Kosmehl
  • Klaus-Jürgen Stiller
  • Alexander Berndt
  • Michael Eiselt
  • Jörg Schubert
  • Detlef Katenkamp
ORIGINAL PAPER

DOI: 10.1007/s004320050147

Cite this article as:
Herbst, C., Kosmehl, H., Stiller, KJ. et al. J Cancer Res Clin Oncol (1998) 124: 141. doi:10.1007/s004320050147

Abstract

A high microvessel density is suspected to favour tumour progression and the occurrence of metastasis. To elucidate the significance of abundant vessels for the behaviour of human renal carcinomas, the microvessel density of 110 renal cell carcinomas was correlated to pT category, nuclear grade, proliferative activity, occurrence of metastasis and relapse-free survival interval. The microvessels were quantified using CD31 immunostaining of endothelial cells and computer-aided image analysis. The rules for reproducible microvessel counting, as defined by Weidner, were strictly observed. A statistically significant relationship between the microvessel density and nuclear grade, proliferative activity, occurrence of metastasis and relapse-free survival was found; only for tumour size could no such relation be seen. Perplexingly, there is a diminution of microvessel density in association with increasing nuclear grade, proliferative activity, relapse-free survival interval and frequency of metastasis. This finding is contradictory to the hypothesis that an increasing microvessel density indicates a worsening prognosis.

Key words Renal cell carcinoma Microvessel density CD 31 immunohistochemistry Image analysis Prognostic factor 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Cordula Herbst
    • 1
  • Hartwig Kosmehl
    • 1
  • Klaus-Jürgen Stiller
    • 1
  • Alexander Berndt
    • 1
  • Michael Eiselt
    • 2
  • Jörg Schubert
    • 3
  • Detlef Katenkamp
    • 1
  1. 1.Institute of Pathology, Friedrich Schiller University, D-07740 Jena, Germany. Tel.: +49 3641 933 625, fax: +49 3641 933 111, e-mail: kosmehl@bach.med.uni-jena.deDE
  2. 2.Institute of Pathophysiology, Friedrich Schiller University, Jena, GermanyDE
  3. 3.Clinic of Urology, Friedrich Schiller University, Jena, GermanyDE

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