Journal of Cancer Research and Clinical Oncology

, Volume 127, Issue 4, pp 258–264

Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator

  • Hiroyuki Nakagawa
  • Yasuhiko Kiyozuka
  • Yoshiko Uemura
  • Hideto Senzaki
  • Nobuaki Shikata
  • Koshiro Hioki
  • Airo Tsubura
ORIGINAL PAPER

DOI: 10.1007/s004320000190

Cite this article as:
Nakagawa, H., Kiyozuka, Y., Uemura, Y. et al. J Cancer Res Clin Oncol (2001) 127: 258. doi:10.1007/s004320000190

Abstract

Resveratrol is a naturally occurring product found in grapes and wine. The effect of synthetic resveratrol on the growth of estrogen receptor (ER)-positive (KPL-1 and MCF-7) and -negative (MKL-F) human breast cancer cell lines was examined. Resveratrol at low concentrations caused cell proliferation in ER-positive lines (KPL-1, ≤22 μM; MCF-7, ≤4 μM) whereas at high concentrations (≥44 μM) it caused suppression of cell growth in all three cell lines examined. Growth suppression was due to apoptosis as seen by the appearance of a sub-G1 fraction. The apoptosis cascade up-regulated Bax and Bak protein, down-regulated Bcl-xL protein, and activated caspase-3. Resveratrol (52–74 μM) antagonized the effect of linoleic acid, a potent breast cancer cell stimulator, and suppressed the growth of both ER-positive and -negative cell lines. Thus, resveratrol could be a promising anticancer agent for both hormone-dependent and hormone-independent breast cancers, and may mitigate the growth stimulatory effect of linoleic acid in the Western-style diet.

Key words Resveratrol Linoleic acid Apoptosis Bax Bak Bcl-xL Caspase-3 

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Hiroyuki Nakagawa
    • 1
  • Yasuhiko Kiyozuka
    • 1
  • Yoshiko Uemura
    • 1
  • Hideto Senzaki
    • 1
  • Nobuaki Shikata
    • 1
  • Koshiro Hioki
    • 2
  • Airo Tsubura
    • 1
  1. 1.Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan Tel.: +81-6-69939431; Fax +81-6-69925023 e-mail: tsubura@takii.kmu.ac.jpJP
  2. 2.Department of Surgery II, Kansai Medical University, Moriguchi, Osaka, JapanJP

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