Circular RNAs: pivotal molecular regulators and novel diagnostic and prognostic biomarkers in non-small cell lung cancer
Circular RNAs (circRNAs), a large class of non-coding RNAs with covalently closed-loop structures, are abundant, stable, conserved, and have tissue and developmental-stage specificities. The biological functions of circRNAs are varied. Moreover, circRNAs participate in various pathological processes, especially in multiple cancers. Lung cancer is the most frequent malignant tumor worldwide. Many studies have suggested that circRNAs are pivotal in non-small cell lung cancer. This article aims to provide a retrospective review of the latest research on the functions of circRNAs in non-small cell lung cancer. In particular, we focus our discussion on the role of circRNAs in cell-cycle regulation and the epithelial–mesenchymal transition, and also discuss the known regulatory molecular mechanisms of circRNAs in non-small cell lung cancer.
We reviewed the literature on circRNAs and non-small cell lung cancer from PubMed databases. Specifically, we focused on the roles and mechanisms of circRNAs in regulating the cell cycle and the epithelial–mesenchymal transition.
Dysregulation of circRNAs is closely correlated with proliferation, migration, and invasion of non-small cell lung cancer, especially in terms of modulating cell-cycle regulation and the epithelial–mesenchymal transition.
Taken together, circRNAs have potential as biomarkers for the diagnosis, prognosis, and treatment of non-small cell lung cancer.
KeywordsCircular RNAs Non-small cell lung cancer Biomarker Cell cycle Epithelial–mesenchymal transition
All of the data generated or analyzed during this study are included in this published article.
JZ and JL contributed to the conception of the study. LZ, GM, QW, and XL contributed significantly to the analysis of data and preparation of the manuscript. CL performed data analyses and wrote the manuscript. All of the authors read and approved the final manuscript.
Funding was provided by the National Natural Science Foundation of China (Grant no. 81672297).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
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