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Effects of metabolic syndrome on the prevalence of prostate cancer: historical cohort study using the national health insurance service database

  • Sangjun Yoo
  • Sohee Oh
  • Juhyun Park
  • Sung Yong Cho
  • Min Chul Cho
  • Hwancheol Son
  • Hyeon JeongEmail author
Original Article – Clinical Oncology
  • 72 Downloads

Abstract

Purpose

To estimate the effect of metabolic syndrome (MetS) on the prevalence of prostate cancer using a large retrospective cohort with a 5-year follow-up duration.

Methods

National Health Insurance Service health checkup cohort was used for the study. In total, 130,342 men included in the health checkup cohort in 2009 were divided into two groups according to the presence of prostate cancer. The prevalence of prostate cancer from 2009 to 2013 was cumulatively calculated from 2003. A generalized estimating equation was used to assess the effect of MetS and its component on the prevalence of prostate cancer after adjusting for other variables.

Results

Prostate cancer was present in 2369 men (1.8%) in 2009. The prevalence of prostate cancer was significantly higher in patients with MetS than in those without MetS throughout the entire follow-up duration. Multivariable analysis showed that in addition to year at evaluation and age, the presence of MetS was associated with an increased prevalence of prostate cancer. Alcohol consumption and smoking levels were negatively associated with the prevalence of prostate cancer. Among MetS components, decreased high density lipoprotein (HDL)-cholesterolemia and central obesity were associated with an increased prevalence of prostate cancer after adjusting for other variables.

Conclusion

MetS and its components, especially decreased HDL-cholesterol levels and central obesity, were related to the increased prevalence of prostate cancer. Preventing MetS, maintaining high HDL-cholesterol level, and maintaining low waist circumference might be useful ways for decreasing the prevalence of prostate cancer.

Keywords

Cohort studies Dyslipidemia Metabolic syndrome X Prostate cancer 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animal

Not applicable.

Informed consent

Informed consent waive by IRB.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of UrologySeoul National University Boramae Medical CenterSeoulRepublic of Korea
  2. 2.Department of BiostatisticsSeoul National University Boramae Medical CenterSeoulRepublic of Korea
  3. 3.Department of UrologySeoul National University HospitalSeoulRepublic of Korea

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