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Multiple functions of HuR in urinary tumors

  • Fa Zhang
  • Zhonglin Cai
  • Haidi Lv
  • Wenjuan Li
  • Mengtian Liang
  • Xupan Wei
  • Fenghai ZhouEmail author
Review – Cancer Research
  • 59 Downloads

Abstract

Purpose

Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors’ biology and explore the potential role in therapeutic strategies aimed at targeting this molecule in cancer cells.

Methods

The relevant literature from PubMed and Medline databases is reviewed in this article.

Results

Increasing evidence supports that HuR plays a critical role in urinary tumors’ biology because it regulates the expression of many urinary tumors-associated molecules through post-transcriptional regulatory mechanisms (including mRNA trafficking, mRNA decay and protein translation). Recent studies have demonstrated that HuR is associated with chemoresistance of urinary tumors, suggesting that HuR might be a novel therapeutic target and a marker for therapeutic response and prognosis assessment.

Conclusion

HuR is associated with various urinary tumors biological characteristics. Targeted therapy of HuR may become an attractive treatment strategy. What’s more, more preclinical and clinical trials of this targeted strategy are necessary for the treatment of urinary tumors.

Keywords

ELAV1 HuR Urinary neoplasms Biological characteristics Chemotherapy resistance 

Notes

Funding

This study was funded by the Talent Innovation and Enterprise Program of Lanzhou (Grant no. 2015-RC-16).

Compliance with ethical standards

Conflict of interest

Authors have no conflicts of interest to declare.

Ethical approval

This article does not contain any studies with animals performed by any of the authors. This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of UrologyGansu Provincial HospitalLanzhouChina
  2. 2.Department of Urology, Peking Union Medical College Hospital, Peking Union Medical CollegeChinese Academy of Medical SciencesBeijingChina

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