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Journal of Cancer Research and Clinical Oncology

, Volume 144, Issue 9, pp 1785–1792 | Cite as

Evaluation of the effects of sensorimotor exercise on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy

  • Paul Lennart Vollmers
  • Christoph Mundhenke
  • Nicolai Maass
  • Dirk Bauerschlag
  • Stefan Kratzenstein
  • Christoph Röcken
  • Thorsten Schmidt
Original Article – Clinical Oncology

Abstract

Introduction

Breast cancer is the most common cancer disease of women in industrialized countries. Neurotoxic chemotherapy drugs are known to harm peripheral nerves and cause a chemotherapy-induced peripheral neuropathy (CIPN). CIPN is one of the most common adverse events associated with Paclitaxel chemotherapy and may remain present long after the termination of chemotherapy. Thus, it reduces the patients’ quality of life (QoL) both during chemotherapy and onwards, and can impose a danger on breast cancer survivors due to an increased risk of falling and fall-related injuries.

Methods

The aim of this randomized-controlled trial (RCT) (n = 36) (IG: intervention group, n = 17) (CG: control group, n = 19) was to determine whether sensorimotor exercises have a positive effect on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy (Paclitaxel).

Results

As a result, we were able to show significant improvements in postural stability in monopedal stance [left leg 16.17 ± 3.67 vs. 21.55 ± 5.33 (p < 0.001) and right leg 15.14 ± 2.30 vs. 20.85 ± 5.05 (p < 0.001)] and in bipedal stance [T1 vs. T0, − 0.49 (IG) vs. + 1.14 (CG) p = 0.039].

Discussion

These results in posturography correlate with the clinical presentation with intervention group patients scoring significantly better on the Fullerton Advanced Balance Scale [37.71 ± 2.73 vs. 34.47 ± 3.98 (p = 0.004)]. Moderate strength training successfully prevented a strength loss in the IG that was remarkable in the CG (− 1.60 vs. 0.60, p = 0.029). Concerning the psychological parameters assessed via EORTC- and MFI-questionnaires, no significant improvements were found.

Conclusion

Future studies should focus on the correlation of clinical and posturometry findings and subjective QOL such as the long-term-development of CIPN.

Keywords

Breast cancer Mamma-carcinoma Chemotherapy Paclitaxel Taxol Neurotoxic Neuropathy Chemotherapy-induced peripheral polyneuropathy Nerves Sensorimotor exercise Training Exercise intervention Posturometry Posturography Sway area Monopedal stance Bipedal stance Fullterton Advanced Balance Scale FAB Postural instability Risk of falling Fall risk Strength Upper extremity Lower extremity Hand dynamometer Chair rising test Eortc European organization of research and treatment of cancer Qol Quality of life QLQ-C30 CIPN-20 BR-23 Multidimensional Fatigue Inventory MFI-20 Adverse events Survivors 

Notes

Compliance with ethical standards

Conflict of interest

We declare that no conflicts of interest exist. No financial gain is obtained from this study and its findings.

Ethical approval

All procedures performed in studies involving human participants were carried out in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 (and subsequent) Helsinki declaration(s) and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in this study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Paul Lennart Vollmers
    • 1
    • 4
  • Christoph Mundhenke
    • 1
  • Nicolai Maass
    • 1
  • Dirk Bauerschlag
    • 2
  • Stefan Kratzenstein
    • 3
  • Christoph Röcken
    • 2
  • Thorsten Schmidt
    • 2
  1. 1.University Hospital for WomenKielGermany
  2. 2.Comprehensive Cancer Center NorthUniversity of KielKielGermany
  3. 3.Institute of Sports PsychologyUniversity of KielKielGermany
  4. 4.AltenholzGermany

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