Journal of Cancer Research and Clinical Oncology

, Volume 143, Issue 9, pp 1845–1851 | Cite as

Histologic subtype needs to be considered after partial nephrectomy in patients with pathologic T1a renal cell carcinoma: papillary vs. clear cell renal cell carcinoma

  • Sangjun Yoo
  • Dalsan You
  • In Gab Jeong
  • Cheryn Song
  • Bumsik Hong
  • Jun Hyuk Hong
  • Hanjong Ahn
  • Choung-Soo KimEmail author
Original Article – Clinical Oncology



We compared the oncological outcomes of papillary renal cell carcinoma (pRCC) with clear cell renal cell carcinoma (ccRCC) after partial nephrectomy (PN) in patients with pathologic T1a RCC.


After excluding patients with synchronous multiple renal tumors, familial RCC, and pathologic stage T1b or above, 759 patients with ccRCC and 84 patients with pRCC were included. We assessed the impact of histologic subtypes on oncologic outcomes after PN in patients with pathologic T1a RCC (median follow-up duration, 67 months).


There was no difference in patient and tumor characteristics between the 2 groups, except Fuhrman grade (p = 0.006). Kaplan–Meier analysis identified 5-year recurrence-free survival of 98.7 and 95.6% in patients with ccRCC and pRCC, respectively. However, 10-year recurrence-free survival in patients with ccRCC and pRCC was 96.1 and 73.0%, respectively (p < 0.001). Recurrence ≥5 years post surgery was more common in patients with pRCC compared with those with ccRCC (0.3 vs. 4.8%; p < 0.001). In multivariate analysis, pRCC [hazard ratio (HR) 5.309; p = 0.001] was a significant risk factor for recurrence after PN in patients with pathologic T1a RCC, in addition to larger tumor size (HR 1.861; p = 0.038) and Fuhrman grade ≥3 (HR 5.176; p = 0.003).


In patients with pathologic T1a RCC, recurrence after PN occurred more commonly in pRCC compared with ccRCC. As over half of the recurrence cases in patients with pRCC occurred ≥5 years post surgery, a longer follow-up time is required, even for those with pathologic stage T1a disease.


Carcinoma, renal cell Neoplasms by histologic type Recurrence 



Renal cell carcinoma


Papillary renal cell carcinoma


Clear cell renal cell carcinoma


Partial nephrectomy


Radical nephrectomy



There is no financial disclosure from any authors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

This article does not contain any studies with human participants performed by any of the authors.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Sangjun Yoo
    • 1
  • Dalsan You
    • 2
  • In Gab Jeong
    • 2
  • Cheryn Song
    • 2
  • Bumsik Hong
    • 2
  • Jun Hyuk Hong
    • 2
  • Hanjong Ahn
    • 2
  • Choung-Soo Kim
    • 2
    Email author
  1. 1.Department of UrologySeoul National University Boramae Medical CenterSeoulKorea
  2. 2.Department of UrologyAsan Medical Center, University of Ulsan College of MedicineSeoulKorea

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