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Comparing renal function preservation after laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy for clinical T1a renal tumor: using a 3D parenchyma measurement system

  • Liangsong Zhu
  • Guangyu Wu
  • Jiwei Huang
  • Jianfeng Wang
  • Ruiyun Zhang
  • Wen Kong
  • Wei Xue
  • Yiran Huang
  • Yonghui ChenEmail author
  • Jin ZhangEmail author
Original Article – Clinical Oncology

Abstract

Purpose

To compare the renal function preservation between laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy.

Methods

Data were analyzed from 246 patients who underwent laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy for solitary cT1a renal cell carcinoma from January 2013 to July 2015. To reduce the intergroup difference, we used a 1:1 propensity matching analysis. The functional renal parenchyma volume preservation were measured preoperative and 12 months after surgery. The total renal function recovery and spilt GFR was compared. Multivariable logistic analysis was used for predictive factors for renal function decline.

Results

After 1:1 propensity matching, each group including 100 patients. Patients in the laparoscopic radio frequency ablation assisted tumor enucleation had a smaller decrease in estimate glomerular filtration rate at 1 day (−7.88 vs −20.01%, p < 0.001), 3 months (−2.31 vs −10.39%, p < 0.001), 6 months (−2.16 vs −7.99%, p = 0.015), 12 months (−3.26 vs −8.03%, p = 0.012) and latest test (−3.24 vs −8.02%, p = 0.040), also had better functional renal parenchyma volume preservation (89.19 vs 84.27%, p < 0.001), lower decrease of the spilt glomerular filtration rate (−9.41 vs −17.13%, p < 0.001) at 12 months. The functional renal parenchyma volume preservation, warm ischemia time and baseline renal function were the important independent factors in determining long-term functional recovery.

Conclusions

The laparoscopic radio frequency ablation assisted tumor enucleation technology has unique advantage and potential in preserving renal parenchyma without ischemia damage compared to conventional laparoscopic partial nephrectomy, and had a better outcome, thus we recommend this technique in selected T1a patients.

Keywords

Renal tumor Functional renal parenchymal Ablation techniques Three-dimensional volume measurement 

Notes

Compliance with ethical standards

Funding

This study was funded by by National Natural Science Foundation of China (Nos. 81472378, 91129725), Shanghai Committee of Science and Technology (13ZR1425100), and Shanghai Health System Advanced Technology Popularization Project (2013SY024).

Conflict of interest

No conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Liangsong Zhu
    • 1
  • Guangyu Wu
    • 2
  • Jiwei Huang
    • 1
  • Jianfeng Wang
    • 1
  • Ruiyun Zhang
    • 1
  • Wen Kong
    • 1
  • Wei Xue
    • 1
  • Yiran Huang
    • 1
  • Yonghui Chen
    • 1
    Email author
  • Jin Zhang
    • 1
    Email author
  1. 1.Department of Urology, Ren Ji Hospital, School of MedicineShanghai Jiaotong UniversityShanghaiPeople’s Republic of China
  2. 2.Department of Radiology, Ren Ji Hospital, School of MedicineShanghai Jiaotong UniversityShanghaiPeople’s Republic of China

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