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Journal of Cancer Research and Clinical Oncology

, Volume 142, Issue 7, pp 1651–1657 | Cite as

Oncological outcomes of patients with incidental pathological T3a stage small renal cell carcinoma after partial nephrectomy

  • Chunwoo Lee
  • Dalsan You
  • Sangjun Yoo
  • Cheryn Song
  • Bumsik Hong
  • Jun Hyuk Hong
  • Hanjong Ahn
  • Choung-Soo KimEmail author
Original Article – Clinical Oncology

Abstract

Purpose

This study was designed to evaluate and compare the oncological outcomes of patients with pathological T1a (pT1a) small renal cell carcinomas (RCCs) with those with incidental pathological T3a (pT3a) RCCs who have been treated using partial nephrectomy (PN).

Methods

We retrospectively evaluated the records of 1367 consecutive patients who underwent PN for small RCCs (≤4 cm) between 1997 and 2014. The curves for recurrence-free, cancer-specific, and overall survival were estimated using the Kaplan–Meier method. Cox regression analysis was used to estimate the prognostic significance of each variable.

Results

Of the 1367 small RCC patients identified, 1324 (96.8 %) had pT1a lesions and 43 (3.2 %) had pT3a lesions. The median ages of the pT1a and pT3a patients were 53.9 and 58.1 years, respectively. Patients received follow-up for a median of 54 months. The 5- and 10-year RFS rates in patients with pT1a and pT3a RCCs were 98.0 and 95.2 %, and 94.4 and 95.2 %, respectively (P = 0.521). None of the patients with recurrent tumors in the pT3a group have died by the time of the writing of this report. A multivariate Cox proportional hazards model showed that tumor size was a significant predictor of RFS and CSS (P < 0.05). However, pT stage (pT3a vs. pT1a) was not a significant predictor of RFS, CSS, or OS (P = 0.104, P = 0.573, and P = 0.441, respectively).

Conclusions

Our study found that pT3a stage disease following PN for small RCCs (≤4 cm) had similar oncological outcomes to those of pT1a stage.

Keywords

Carcinoma Renal cell Partial nephrectomy T1a T3a Oncological outcome 

Notes

Compliance with ethical standards

Conflict of interest

The authors report no conflict of interest.

Ethical approval

This study was performed with the approval and oversight of the Institutional Review Board of Asan Medical Center.

Human rights

This article does not contain any studies on human participants that were performed by any of the authors.

Informed consent

Informed consent was not obtained from all of the individual participants included in this study because of its retrospective design.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Chunwoo Lee
    • 1
  • Dalsan You
    • 2
  • Sangjun Yoo
    • 2
  • Cheryn Song
    • 2
  • Bumsik Hong
    • 2
  • Jun Hyuk Hong
    • 2
  • Hanjong Ahn
    • 2
  • Choung-Soo Kim
    • 2
    Email author
  1. 1.Department of Urology, Gyeongsang National University Changwon HospitalGyeongsang National University School of MedicineChangwonKorea
  2. 2.Department of Urology, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

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