Journal of Cancer Research and Clinical Oncology

, Volume 142, Issue 7, pp 1509–1520 | Cite as

Hepatic resection during cytoreductive surgery for primary or recurrent epithelial ovarian cancer

  • Maria Luisa Gasparri
  • Giovanni Grandi
  • Daniele Bolla
  • Beat Gloor
  • Sara Imboden
  • Pierluigi Benedetti Panici
  • Michael D. Mueller
  • Andrea PapadiaEmail author
Review – Clinical Oncology



Surgical cytoreduction remains a cornerstone in the management of patients with advanced and recurrent epithelial ovarian cancer. Parenchymal liver metastases determine stage VI disease and are commonly considered a major limit in the achievement of an optimal cytoreduction. The purpose of this manuscript was to discuss the rationale of liver resection and the morbidity related to this procedure in advanced and recurrent ovarian cancer.


A search of the National Library of Medicine’s MEDLINE/PubMed database until March 2015 was performed using the keywords: “ovarian cancer,” “hepatic,” “liver,” and “metastases.”


In patients with liver metastases, hepatic resection is associated with a similar prognosis as stage IIIC patients. The length of the disease-free interval between primary diagnosis and occurrence of liver metastases, as well as residual disease after resection, is the most important prognostic factors. In addition, the number of liver lesions, resection margins, and the gynecologic oncology group performance status seem to play also an important role in determining outcome.


In properly selected patients, liver resections at the time of cytoreduction increase rates of optimal cytoreduction and improve survival in advanced-stage and recurrent ovarian cancer patients.


Cytoreduction Debulking surgery Liver metastases Hepatectomy Ovarian cancer Recurrent ovarian cancer 



No funding source supported the present investigation.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest.

Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Maria Luisa Gasparri
    • 1
    • 3
  • Giovanni Grandi
    • 2
  • Daniele Bolla
    • 3
  • Beat Gloor
    • 4
  • Sara Imboden
    • 3
  • Pierluigi Benedetti Panici
    • 1
  • Michael D. Mueller
    • 3
  • Andrea Papadia
    • 3
    Email author
  1. 1.Department of Obstetrics and Gynecology“Sapienza” University of RomeRomeItaly
  2. 2.Department of Obstetrics and GynecologyUniversity of ModenaModenaItaly
  3. 3.Department of Obstetrics and Gynecology, InselspitalBerne UniversityBerneSwitzerland
  4. 4.Department of Surgery, InselspitalBerne UniversityBerneSwitzerland

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