Journal of Cancer Research and Clinical Oncology

, Volume 142, Issue 1, pp 287–293 | Cite as

The risk of female malignancies after fertility treatments: a cohort study with 25-year follow-up

  • R. Kessous
  • E. Davidson
  • M. Meirovitz
  • R. Sergienko
  • E. Sheiner
Original Article - Clinical Oncology



To investigate whether an association exists between a history of fertility treatments and future risk of female malignancies.

Study design

A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vitro fertilization (IVF) and ovulation induction (OI). Deliveries occurred between the years 1988–2013, with a mean follow-up duration of 12 years. Excluded from the study were women with known genetic predisposition for malignancies or known malignancies prior to the index pregnancy. Female malignancies were divided into specific types including ovarian, uterine, breast and cervix. Kaplan–Meier survival curve was used to estimate cumulative incidence of malignancies. Cox proportional hazard models were used to estimate the adjusted hazard ratios (HRs) for female malignancy.


During the study period, 106,031 women met the inclusion criteria; 4.1 % (n = 4363) occurred in patients following fertility treatments. During the follow-up period, patients with a history of IVF treatments had a significantly increased risk of being diagnosed with ovarian and uterine cancer as compared to patients after OI and patients with no history of fertility treatments. Cox proportional hazard models were constructed for ovarian and uterine cancer separately, controlling for confounders such as maternal age and obesity. A history of IVF treatment remained independently associated with ovarian and uterine cancer (adjusted HR 3.9; 95 % CI 1.2–12.6; P = 0.022 and adjusted HR 4.6; 95 % CI 1.4–14.9; P = 0.011; respectively).


IVF treatments pose a significant risk of subsequent long-term ovarian and uterine cancer.


Female malignancies Uterine cancer Ovarian cancer In vitro fertilization Ovulation induction 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • R. Kessous
    • 1
  • E. Davidson
    • 3
  • M. Meirovitz
    • 1
  • R. Sergienko
    • 2
  • E. Sheiner
    • 1
  1. 1.Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical CenterBen-Gurion University of the NegevBeershebaIsrael
  2. 2.Department of Public HealthBen-Gurion University of the NegevBeershebaIsrael
  3. 3.Faculty of Health Sciences, Soroka University Medical Center, Clalit Health Services (Southern District)Ben-Gurion University of the NegevBeershebaIsrael

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