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Journal of Cancer Research and Clinical Oncology

, Volume 140, Issue 12, pp 2077–2086 | Cite as

Diagnostic accuracy of EUS and CT of vascular invasion in pancreatic cancer: a systematic review

  • RenBao YangEmail author
  • ManPeng Lu
  • XiaoXing Qian
  • Jiong Chen
  • Liang Li
  • JiaWen Wang
  • YouQian Zhang
Review – Clinical Oncology

Abstract

Objective

The objective of this study was to summarize the accuracy of preoperative vascular invasion with endoscopic ultrasound (EUS) and computed tomography (CT) test performance in pancreatic cancer with meta-analysis

Method

Two reviewers searched MEDLINE database to identify relevant studies. The reference lists of the trials were manually searched. Included studies used surgical and/or histological findings as the “gold standard,” and provided sufficient data to construct a diagnostic 2 × 2 table. A statistical program of Meta-Disc was used to calculate the pooled sensitivity, specificity, positive LR, negative LR, DOR, and the SROC curve. Publication bias was assessed by Deeks’ asymmetry test. Sensitivity analysis and subgroup analysis were calculated to down the heterogeneity. Meta-regression was calculated to evaluate potential sources of heterogeneity

Result

A total of 30 studies with 1,554 patients were included for the analysis, nine of these studies compared EUS with CT to assess the diagnostic efficiency The pooled sensitivity of EUS and CT was 72 % (95 % CI 67–77 %) and 63 % (95 % CI 58–67 %), and the pooled specificity of EUS and CT was 89 % (95 % CI 86–92 %) and 92 % (95 % CI 90–94 %), respectively. The positive LR of EUS and CT was 5.14 (95 % CI 3.14–8.40) and 6.21 (95 % CI 3.96–9.71), and the negative LR was 0.36 (95 % CI 0.25–0.52) and 0.41 (95 % CI 0.31–0.55), respectively. The AUCs of EUS and CT were 0.9037 and 0.8948. The subgroup analysis of nine studies performed both EUS and CT showed CT scan with a lower sensitivity of 48 % (95 % CI 0.40–0.56), when compared to EUS of 69 % (95 % CI 0.61–0.77). The overall AUCs of CT scan appear to be lower (AUCs = 0.8589), compared with EUS (AUCs = 0.9379)

Conclusion

EUS performed better than CT in differentiating vascular invasion preoperative on pancreatic cancer. EUS could provide other additional information when compared with CT.

Keywords

Pancreatic cancer Endoscopic ultrasound Computed tomography Vascular invasion Meta-analysis 

Notes

Conflict of interest

None

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • RenBao Yang
    • 1
    Email author
  • ManPeng Lu
    • 1
  • XiaoXing Qian
    • 1
  • Jiong Chen
    • 2
  • Liang Li
    • 1
  • JiaWen Wang
    • 1
  • YouQian Zhang
    • 1
  1. 1.Department of General SurgeryAnhui Medical University Affiliated HeFei Hospital, Hefei Second People’s HospitalHefeiChina
  2. 2.Department of General SurgeryAffiliated Provincial Hospital of AnHui Medical UniversityHefeiChina

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