Heat shock protein 22 overexpression is associated with the progression and prognosis in gastric cancer
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The heat shock protein 22 (HSP22) is associated with tumor proliferation and protects tumor cell from apoptosis in many malignancies. However, the role of HSP22 in gastric cancer has not been thoroughly elucidated. The aim was to determine the relationship of HSP22 expression with clinicopathological parameters and prognosis in gastric cancer and estimate the alteration of HSP22 expression after neoadjuvant chemotherapy.
HSP22 and matrix metallopeptidase 9 (MMP-9) antigen expressions were evaluated by immunohistochemistry in 129 gastric carcinoma samples. Univariate and multivariate analyses were performed to determine the association between HSP22 expression and prognosis. The response of HSP22 was assessed in 47 patients who received neoadjuvant chemotherapy.
HSP22 protein expression was significantly associated with tumor size, depth invasion, lymph node metastasis and stage of disease (all P < 0.05). In univariate and multivariate analyses, HSP22 was an independent prognostic factor for both overall survival (OS) and recurrence-free survival (RFS) (P = 0.003 and P = 0.004, respectively). Furthermore, HSP22 overexpression was associated with a poor prognosis in all patients and in patients subgroups stratified by tumor size, depth invasion and lymph node metastasis. In addition, HSP22 was significantly correlated with MMP-9 among 129 gastric cancer tissues (P < 0.001). Patients who had MMP-9 overexpression had poor OS and shorter RFS. Moreover, the alteration of HSP22 was not comparable in 47 patients who underwent neoadjuvant chemotherapy.
HSP22 plays an important role on tumor aggressiveness and prognosis and may act as a promising target for prognostic prediction.
KeywordsHeat shock protein 22 Gastric cancer Aggressiveness Prognosis
Heat shock protein 22
Matrix metallopeptidase 9
Union International Cancer Control
We gratefully acknowledge the clinical data provided by the pathology department (Affiliated Hospital of Guilin Medical University). This work was supported by a Grant of National Natural Science Foundation of China (Nos. 81360530).
Conflict of interest
The authors declare that there are no conflicts of interest or financial disclosures.
- Bang YJ, Van Cutsem E, Feyereislova A et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of her2-positive advanced gastric or gastro-oesophageal junction cancer (toga): a phase 3, open-label, randomised controlled trial. Lancet 376:687–697PubMedCrossRefGoogle Scholar
- Smith CC, Yu YX, Kulka M et al (2000) A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine pk and is expressed in melanoma cells. J Biol Chem 275:25690–25699PubMedCrossRefGoogle Scholar
- Wu AW, Xu GW, Wang HY et al (2007) Neoadjuvant chemotherapy versus none for resectable gastric cancer. Cochrane Database Syst Rev (2):CD005047Google Scholar