Journal of Cancer Research and Clinical Oncology

, Volume 140, Issue 7, pp 1205–1210 | Cite as

Prognostic significance of serum lactate dehydrogenase level in osteosarcoma: a meta-analysis

  • Jian Chen
  • Meng-xiong Sun
  • Ying-qi Hua
  • Zheng-dong Cai
Original Article – Clinical Oncology



A number of studies have investigated the role of serum lactate dehydrogenase (LDH) level in patients with osteosarcoma but have yielded inconsistent and inconclusive results. Thus, we conducted a meta-analysis to assess its prognostic value more precisely.


Systematic computerized searches of PubMed, Embase and Web of Science databases were performed. The pooled hazard ratio (HR) with 95 % confidence intervals (95 % CI) of overall survival was used to assess the prognostic role of serum LDH level.


Ten studies published between 1997 and 2013 with a total of 943 osteosarcoma patients were included. Overall, the pooled HR for all ten eligible studies evaluating high LDH level on overall survival was 1.92(95 % CI 1.53–2.40). Sensitivity analysis suggested that the pooled HR was stable and omitting a single study did not change the significance of the pooled HR. Funnel plots and Egger’s tests revealed there was some possibility of publication bias risk in the meta-analysis.


This meta-analysis shows that high serum LDH level is obviously associated with lower overall survival rate in patients with osteosarcoma, and it is an effective biomarker of prognosis.


LDH Osteosarcoma Prognosis Meta-analysis 


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Orthopaedics, Shanghai First People’s HospitalNanjing Medical UniversityShanghaiChina

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