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Journal of Cancer Research and Clinical Oncology

, Volume 140, Issue 7, pp 1067–1073 | Cite as

A systematic review of the epidemiological literature on the risk of urological cancers in systemic lupus erythematosus

  • Hou-bao Huang
  • Shu-chuan Jiang
  • Jie Han
  • Qing-shui Cheng
  • Chang-bin Dong
  • Cai-ming Pan
Review - Cancer Research

Abstract

Purpose

A grow body of studies has evaluated the risk of development of urological cancer in systemic lupus erythematosus (SLE) with inconclusive results. To clarify the association, a meta-analysis approach was performed to assess the published evidence on urological cancers and SLE.

Methods

Relevant English electronic databases were systematic searched for published studies characterizing the risk of developing urological cancer as a result of SLE. Standardized incidence rate (SIR) with its 95 % confidence interval (CI) of each study was combined using a fixed-/random-effect model in STATA software.

Results

A total of 12 papers including 68366 SLE patients were suitable for meta-analysis. Of these, 9 reported the SIR for prostate cancer, 7 for bladder cancer and 6 for kidney cancer. Summary SIRs were 0.77 (95 % CI 0.69–0.87, P < 0.001); 1.75 (95 % CI 0.94–3.23, P = 0.075) and 2.29 (95 % CI 1.25–4.18, P = 0.007), respectively. Significant heterogeneity was noticed in subgroups of bladder and kidney cancer. No obvious publication bias was detected.

Conclusions

Findings from this meta-analysis indicate that SLE is associated with a decreased risk of prostate cancer and an increased risk of kidney cancer.

Keywords

Urological cancer Systemic lupus erythematosus Meta-analysis SIR 

Notes

Conflict of interest

None.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Hou-bao Huang
    • 1
  • Shu-chuan Jiang
    • 1
  • Jie Han
    • 1
  • Qing-shui Cheng
    • 1
  • Chang-bin Dong
    • 1
  • Cai-ming Pan
    • 1
  1. 1.Department of Urology, Yiji Shan HospitalThe First Affiliated Hospital of Wannan Medical CollegeWuhuChina

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