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CEA/CA72-4 levels in peritoneal lavage fluid are predictive factors in patients with gastric carcinoma

  • Manabu Yamamoto
  • Keiji Yoshinaga
  • Ayumi Matsuyama
  • Shinichi Tsutsui
  • Teruyoshi Ishida
Original Paper

Abstract

Purpose

Increased levels of tumor marker in intra-operative peritoneal lavage are associated with an earlier detection of recurrent peritoneal dissemination.

Method

Intra-operative peritoneal lavage samples from 193 patients with gastric cancer were obtained to determine the levels of the tumor markers, carcinoembryonic antigen (CEA) and cancer-related antigen 72-4 (CA72-4) using a chemiluminescent enzyme immunoassay.

Results

The peritoneal lavage CEA (CY-CEA), CA72-4 (CY-CA72-4) and serosal invasion were independent factors predicting the peritoneal dissemination including CY(+). The patients were divided into four groups on the basis of peritoneal lavage tumor marker status; group A: CY-CEA (−), CY-CA72-4 (−) group (CEA < 0.5 ng/ml, CA72-4 < 1.3 U/ml); group B: CY-CEA (−), CY-CA72-4 (+) group (CEA < 0.5 ng/ml, CA72-4 ≥ 1.3 U/ml); group C: CY-CEA (+), CY-CA72-4 (−) group (CEA ≥ 0.5 ng/ml, CA72-4 < 1.3 U/ml); and group D: CY-CEA (+), CY-CA72-4 (+) group (CEA ≥ 0.5 ng/ml, CA72-4 ≥ 1.3 U/ml). The 5-year survival among the patients in groups A, B, C and D was 87, 68, 38 and 20 %, respectively (p < 0.0001).

Conclusion

Combined analysis of these markers is therefore considered to be helpful for accurately determining sites of recurrence and the prognosis in advanced gastric cancer patients.

Keywords

Tumor marker Tumor recurrence Gastric cancer Peritoneal dissemination Prognosis 

Abbreviations

CY(+)

Peritoneal lavage cytological positive

CEA

Carcinoembryonic antigen

CA72-4

Cancer-related antigen 72-4

CA125

Cancer antigen 125

CY-CEA

The peritoneal lavage carcinoembryonic antigen

CY-CA72-4

The peritoneal lavage cancer-related antigen 72-4

Notes

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Manabu Yamamoto
    • 1
    • 2
  • Keiji Yoshinaga
    • 1
  • Ayumi Matsuyama
    • 1
  • Shinichi Tsutsui
    • 1
  • Teruyoshi Ishida
    • 1
  1. 1.Department of SurgeryHiroshima Atomic Bomb Survivors HospitalHiroshimaJapan
  2. 2.Department of Gastroenterological SurgeryNational Kyushu Cancer CenterFukuokaJapan

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