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Efficacy and toxicity of Trastuzumab and Paclitaxel plus Capecitabine in the first-line treatment of HER2-positive metastatic breast cancer

  • Onder TonyaliEmail author
  • Mustafa Benekli
  • Veli Berk
  • Ugur Coskun
  • Metin Ozkan
  • Ramazan Yildiz
  • Emel Ucgul
  • Alper Sevinc
  • Dogan Uncu
  • Umut Demirci
  • Suleyman Buyukberber
  • Anatolian Society of Medical Oncology (ASMO)
Original Paper

Abstract

Purpose

Combinations of trastuzumab with paclitaxel or capecitabine are effective therapies in human epidermal growth factor 2 (HER2)-positive metastatic breast cancer (MBC). This retrospective study evaluated the efficacy and toxicity of trastuzumab and paclitaxel plus capecitabine in the first-line therapy for patients with HER2-positive MBC.

Methods

A total of 40 patients with HER2-positive MBC treated between January 2008 and January 2011 were evaluated retrospectively in 6 institutions. Three patients with performance score of 3 who died before response assessment were excluded from the study. The patients were given trastuzumab 8 mg/kg loading dose followed by then 6 mg/kg dose on day 1 and paclitaxel 175 mg/m2 on day 1 plus capecitabine 825 mg/m2 twice daily on days 1–14 every 3 weeks.

Results

A total of 287 cycles of chemotherapy were administered with a median of 8 treatment cycles per patient (range 3–12). Median follow-up period was 24.7 months (range 4.7–51). There were 9 patients (24.3 %) with complete responses, 21 (56.8 %) with partial responses, 4 (10.8 %) with stable disease and 3 (8.1 %) with progressive disease resulting in an overall response rate (ORR) of 81.1 %. Median progression-free survival and overall survival were 14 and 38.4 months, respectively. Rates of grade 3 adverse events were neutropenia (n = 4, 10.8 %), cardiac dysfunction (n = 1, 2.7 %), hand-foot syndrome (n = 2, 5.4 %), nausea (n = 2, 5.4 %), vomiting (n = 2, 5.4 %), fatigue (n = 1, 2.7 %), diarrhea (n = 1, 2.7 %), neuropathy (n = 1, 2.7 %) and alopecia (n = 1, 2.7 %).

Conclusions

Combination of trastuzumab and paclitaxel plus capecitabine is an effective and well-tolerated regimen in the first-line therapy for women with HER2-positive MBC.

Keywords

Chemotherapy Breast cancer Metastasis HER2 

Notes

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Onder Tonyali
    • 1
    Email author
  • Mustafa Benekli
    • 1
  • Veli Berk
    • 2
  • Ugur Coskun
    • 1
  • Metin Ozkan
    • 2
  • Ramazan Yildiz
    • 3
  • Emel Ucgul
    • 4
  • Alper Sevinc
    • 5
  • Dogan Uncu
    • 6
  • Umut Demirci
    • 4
  • Suleyman Buyukberber
    • 1
  • Anatolian Society of Medical Oncology (ASMO)
  1. 1.Division of Medical Oncology, Department of Internal Medicine, Faculty of MedicineGazi UniversityBesevler, AnkaraTurkey
  2. 2.Division of Medical Oncology, Department of Internal Medicine, Faculty of MedicineErciyes UniversityKayseriTurkey
  3. 3.Department of Medical OncologyDr. Lutfi Kirdar Kartal Education and Research HospitalIstanbulTurkey
  4. 4.Department of Medical OncologyAnkara Ataturk Education and Research HospitalAnkaraTurkey
  5. 5.Division of Medical Oncology, Department of Internal Medicine, Faculty of MedicineGaziantep UniversityGaziantepTurkey
  6. 6.Department of Medical OncologyAnkara Numune Education and Research HospitalAnkaraTurkey

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