Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round
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Low-dose multislice-CT (MSCT) detects many early-stage lung cancers with good prognosis, but whether it decreases lung cancer mortality and at which costs is yet insufficiently explored. Scope of the present study is to examine within a common European effort whether MSCT screening is capable to reduce the lung cancer mortality by at least 20 % and at which amount of undesired side effects this could be achieved.
Overall 4,052 heavy smoking men and women were recruited by a population-based approach and randomized into a screening arm with five annual MSCT screens and an initial quit-smoking counseling, and a control arm with initial quit-smoking counseling and five annual questionnaire inquiries.
In the first screening round, 2,029 participants received a MSCT providing 1,488 negative and 540 suspicious screens with early recalls (early recall rate 26.6 %) leading to 31 biopsies (biopsy rate 1.5 %) and 22 confirmed lung cancers (detection rate 1.1 %). Among the lung cancers, 15 were adenocarcinomas, 3 squamous cell carcinomas, one small-cell lung cancer, and 3 others, whereby 18 were in clinical stage I, one in stage II, and 3 in stage III. One interval cancer occurred.
The indicated performance indicators fit into the range observed in comparable trials. The study continues finalizing the second screening round and for the first participants even the last screening round. The unresolved issue of the precise amount of side effects and the high early recall rate precludes currently the recommendation of MSCT as screening tool for lung cancer.
KeywordsEpidemiology Lung cancer screening LUSI Multislice-CT RCT
Numerous colleagues contributed to the success of the study. The MSCTs were carried out by Jessica Engelhart and Martina Jochim. The database was set up and managed (2007–2011) by Simon Roether. Data entry, invitation of participants, and time schedule coordination by Angelika Bari and Andrea Albrecht, quit-smoking counseling by Monika Bade and Vera Bähr, processing and storage of blood specimen by Kirsten Lenner-Fertig and Ulrike von Seydlitz-Kurzbach. The study was supported in 2007–2010 by the German Research Foundation (BE 2486/2-1) and the Dietmar-Hopp-Stiftung, and is currently (2010–2013) supported by the German Research Foundation (BE 2486/2-2), and the members of the German Center for Lung Research by the German Research Ministry (BMBF-DZL).
Conflict of interest
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