Journal of Cancer Research and Clinical Oncology

, Volume 138, Issue 2, pp 341–346 | Cite as

Oral tongue cancer patients show a better overall survival than base of tongue cancer patients

  • Liuyang Zhang
  • Xuan Zhou
  • Xiaofeng Yao
  • Yansheng Wu
  • Qiang Zhang
  • Lun Zhang
Original Paper



The purpose of this study was to compare the prognosis of oral tongue cancer patients and base of tongue cancer patients.


One hundred oral tongue cancer patients (group A) were matched with 50 base of tongue cancer patients (group B) for gender, age, T-stage, and tumor differentiation in this study. Survival rate was performed using the Kaplan–Meier analysis, and multivariate analysis was conducted using the Logistic regression model.


There was difference in the survival rate between the two groups. Three- and 5-year OS (overall survival) of the two groups were 65.0, 51.0% for group A and 40.0, 28.0% for group B, respectively. For the two groups, 3- and 5-year DSS (disease-specific survival) were 61.0, 46.0% for group A and 38.0, 26.0% for group B, respectively. Multivariate analysis showed that recurrence (P = 0.019) and regional lymph node metastasis (P = 0.043) were significant between the group A and group B patients.


The oral tongue cancer patients had a better prognosis than base of tongue cancer patients. The difference in prognosis between the oral tongue cancer and the base of tongue cancer patients in this study was closely associated with the recurrence and regional lymph node metastasis. We conclude that the individual treatment should be used for base of tongue cancer patients.


Squamous cell carcinoma Base of tongue Oral tongue Disease characteristics Prognostic factors 



The authors thank Jon Teng for help with modifying the paper.

Conflict of interest



  1. Attner P, Du J, Nasman A et al (2010) The role of human papillomavirus in the increased incidence of base of tongue cancer. Int J Cancer 126:2879–2884PubMedGoogle Scholar
  2. Birnbaum A, Dipetrillo T, Rathore R et al (2010) Cetuximab, paclitaxel, carboplatin, and radiation for head and neck cancer: a toxicity analysis. Am J Clin Oncol 33:144–147PubMedGoogle Scholar
  3. Bonner JA, Harari PM, Giralt J et al (2010) Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 11:21–28PubMedCrossRefGoogle Scholar
  4. Gorsky M, Epstein JB, Oakley C, Le ND, Hay J, Stevenson-Moore P (2004) Carcinoma of the tongue: a case series analysis of clinical presentation, risk factors, staging, and outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:546–552PubMedCrossRefGoogle Scholar
  5. Hammarstedt L, Lu Y, Marklund L, Dalianis T, Munck-Wikland E, Ye W (2011) Differential survival trends for patients with tonsillar, base of tongue and tongue cancer in Sweden. Oral Oncol 47:636–641PubMedCrossRefGoogle Scholar
  6. Harrison LB, Lee HJ, Pfister DG et al (1998) Long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue. Head Neck 20:668–673PubMedCrossRefGoogle Scholar
  7. Ho HC, Lee MS, Hsiao SH et al (2008) Squamous cell carcinoma of the oral cavity in young patients: a matched-pair analysis. Eur Arch Otorhinolaryngol 265(Suppl 1):S57–S61PubMedCrossRefGoogle Scholar
  8. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90PubMedCrossRefGoogle Scholar
  9. Kies MS, Holsinger FC, Lee JJ et al (2010) Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. J Clin Oncol 28:8–14PubMedCrossRefGoogle Scholar
  10. Kraus DH, Vastola AP, Huvos AG, Spiro RH (1993) Surgical management of squamous cell carcinoma of the base of the tongue. Am J Surg 166:384–388PubMedCrossRefGoogle Scholar
  11. Lam L, Logan RM, Luke C (2006) Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977–2001. Aust Dent J 51:16–22PubMedCrossRefGoogle Scholar
  12. Lam L, Logan RM, Luke C, Rees GL (2007) Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004. Oral Oncol 43:150–158PubMedCrossRefGoogle Scholar
  13. Lill C, Kornek G, Bachtiary B et al (2011) Survival of patients with HPV-positive oropharyngeal cancer after radiochemotherapy is significantly enhanced. Wien Klin Wochenschr 123:215–221PubMedCrossRefGoogle Scholar
  14. Mendenhall WM, Stringer SP, Amdur RJ, Hinerman RW, Moore-Higgs GJ, Cassisi NJ (2000) Is radiation therapy a preferred alternative to surgery for squamous cell carcinoma of the base of tongue? J Clin Oncol 18:35–42PubMedGoogle Scholar
  15. Merlano M, Russi E, Benasso M et al (2011) Cisplatin-based chemoradiation plus cetuximab in locally advanced head and neck cancer: a phase II clinical study. Ann Oncol 22:712–717PubMedCrossRefGoogle Scholar
  16. Moore SR, Johnson NW, Pierce AM, Wilson DF (2000) The epidemiology of tongue cancer: a review of global incidence. Oral Dis 6:75–84PubMedCrossRefGoogle Scholar
  17. Park JO, Sun DI, Cho KJ, Joo YH, Yoo HJ, Kim MS (2010) Clinical outcome of squamous cell carcinoma of the tongue in young patients: a stage-matched comparative analysis. Clin Exp Otorhinolaryngol 3:161–165PubMedCrossRefGoogle Scholar
  18. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108PubMedCrossRefGoogle Scholar
  19. Petersen PE (2009) Oral cancer prevention and control–the approach of the World Health Organization. Oral Oncol 45:454–460PubMedCrossRefGoogle Scholar
  20. Reddy VM, Cundall-Curry D, Bridger MW (2010) Trends in the incidence rates of tonsil and base of tongue cancer in England, 1985–2006. Ann R Coll Surg Engl 92:655–659PubMedCrossRefGoogle Scholar
  21. Rusthoven K, Ballonoff A, Raben D, Chen C (2008) Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma. Cancer 112:345–351PubMedCrossRefGoogle Scholar
  22. Selzer E, Liederer S, Lemaire C et al (2011) Incidence of dermatitis in head and neck cancer patients treated with primary radiotherapy and cetuximab. Strahlenther Onkol 187:373–377PubMedCrossRefGoogle Scholar
  23. Sessions DG, Lenox J, Spector GJ, Chao C, Chaudry OA (2003) Analysis of treatment results for base of tongue cancer. Laryngoscope 113:1252–1261PubMedCrossRefGoogle Scholar
  24. Shim SJ, Cha J, Koom WS et al (2010) Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. Radiat Oncol 5:43PubMedCrossRefGoogle Scholar
  25. Suntharalingam M, Kwok Y, Goloubeva O et al (2011) Phase II study evaluating the addition of cetuximab to the concurrent delivery of weekly carboplatin, paclitaxel, and daily radiotherapy for patients with locally advanced squamous cell carcinomas of the head and Neck. Int J Radiat Oncol Biol Phys. doi: 10.1016/j.ijrobp.2011.02.062
  26. Zhen W, Karnell LH, Hoffman HT, Funk GF, Buatti JM, Menck HR (2004) The National Cancer Data Base report on squamous cell carcinoma of the base of tongue. Head Neck 26:660–674PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Liuyang Zhang
    • 1
  • Xuan Zhou
    • 1
  • Xiaofeng Yao
    • 1
  • Yansheng Wu
    • 1
  • Qiang Zhang
    • 1
  • Lun Zhang
    • 1
  1. 1.The First Department of Head and Neck, Key Laboratory of Cancer Prevention and TherapyTianjin Medical University Cancer Institute and HospitalHexi District, TianjinChina

Personalised recommendations