The TNF-α, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis
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TNF-α-308 G/A, TNF-α-238 G/A, IL-1B-31 T/C, IL-1B-511 C/T, and IL-10-1082 G/A polymorphisms have been reported to influence the risk for hepatocellular carcinoma (HCC) in many studies; however, the results still remains controversial and ambiguous. The aim of this study was to determine more precise estimations for the relationship between TNF-α, IL-1B, and IL-10 polymorphisms and the risk for HCC by meta-analysis.
Electronic searches for all publications were conducted on associations between these variants and HCC in several databases through September 2010. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to estimate the strength of this association in a random-effect model. Twenty studies were identified, involving 2,763 HCC patients and 4,152 controls.
This meta-analysis showed significant association between TNF-α-308 polymorphism and HCC (AA + GA vs. GG: OR = 1.74, 95% CI = 1.12–2.72). In Caucasian and Asian subgroups, OR values (95% CI) were 1.49 (0.58–3.82) and 1.84 (1.06–3.20), respectively. While the ORs for TNF-α-238 G/A, IL-1B-31 T/C, -511 C/T and IL-10-1082 G/A polymorphisms and HCC were 1.37 (0.95–2.00), 1.24 (0.99–1.55), 1.12 (0.66–1.88) and 0.91 (0.74–1.12), respectively. The sensitivity analysis further strengthened the overall strong positive correlations. No publication bias was observed in this study.
TNF-α-308 G/A polymorphism is assumed to confer a higher risk for HCC, especially in Asian population. TNF-α-238 G/A, IL-1B-31 T/C, -511 C/T, and IL-10-1082 G/A polymorphisms were not detected to be related to the risk for HCC.
KeywordsMeta-analysis Polymorphism TNF-α Interleukin Hepatocellular carcinoma
This work was supported by Harbin Special Funds for Research of Scientific and Technological Innovative Talents (No. RC2011QN004139).
Conflict of interest
The authors do not have any conflicts of interest to report with for this manuscript.
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