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Journal of Cancer Research and Clinical Oncology

, Volume 136, Issue 12, pp 1813–1819 | Cite as

Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer

  • Gudrun Knechtel
  • Günter Hofmann
  • Armin Gerger
  • Wilfried Renner
  • Tanja Langsenlehner
  • Joanna Szkandera
  • Gerald Wolf
  • Hellmut Samonigg
  • Peter Krippl
  • Uwe Langsenlehner
Original Paper

Abstract

Purpose

Women with breast cancer that initially involves local lymph nodes have a higher risk for local recurrence or developing metastases. Recent data suggest that germline polymorphism is a significant, previously unrecognized factor in breast cancer progression and metastasis. We assessed the influence of 16 selected common germline polymorphisms in disease-free survival and overall survival among 216 women diagnosed with lymph node-positive breast cancer.

Results

The rare allele of FAS 1377G>A was significantly associated with prolonged disease-free survival (P = 0.012, risk ratio of recurrence (RR) = 0.557, 95% confidence interval (CI) = 0.353–0.878) in univariate analysis. After adjusting for known breast cancer prognostic factors the association remained significant (P = 0.050, RR = 0.500, CI = 0.309–0.809). In overall survival analysis we found a significant association of the FAS 1377G>A (P = 0.040, RR = 0.451, CI = 0.496–1.188) and IL10 592C>A polymorphisms (P = 0.020, RR = 1.707, CI = 1.087–2.680) in the univariate Cox regression. The effect remained statistically significant in the multivariate analysis for the IL10 592C>A polymorphism (P = 0.013, RR 1.841, CI 1.140–2.973). No association was found for MTHFR 677C>T, VEGF 936C>T, CCND1 870G>A, TGFB1 29T>C, FASLG 844C>T, FAS 670A>G, GPB3 825C>T, ITGA2 807C>T, ITGA2 1648G>A, ITGB3 176T>C, MMP1 -1607 1G/2G, MMP3 5A/6A, PTGS2 8473T>C, IL10 592C>A and SULT1A1 638G>A polymorphisms and disease-free survival or overall survival.

Conclusions

Our data suggest that the FAS 1377G>A and IL10 592C>A polymorphisms could modify disease-free and overall survival in women with lymph node-positive breast cancer.

Keywords

Breast cancer Prognosis Polymorphism Lymph node-positive 

Notes

Conflict of interest statements

All authors of the study declare to have no conflict of interest.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Gudrun Knechtel
    • 1
  • Günter Hofmann
    • 1
  • Armin Gerger
    • 1
  • Wilfried Renner
    • 2
  • Tanja Langsenlehner
    • 3
  • Joanna Szkandera
    • 1
  • Gerald Wolf
    • 4
  • Hellmut Samonigg
    • 1
  • Peter Krippl
    • 5
  • Uwe Langsenlehner
    • 6
  1. 1.Department of Internal Medicine, Division of OncologyMedical University GrazGrazAustria
  2. 2.Clinical Institute of Medical and Laboratory DiagnosticsMedical University GrazGrazAustria
  3. 3.Clinic of Therapeutic Radiology and OncologyMedical University GrazGrazAustria
  4. 4.Department of Radiology and Nuclear MedicineGeneral Hospital LeobenLeobenAustria
  5. 5.Department of Internal MedicineRegional Hospital of FuerstenfeldFuerstenfeldAustria
  6. 6.Internal Outpatient DepartmentSteiermaerkische GebietskrankenkasseGrazAustria

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