Journal of Cancer Research and Clinical Oncology

, Volume 135, Issue 8, pp 1117–1123 | Cite as

Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience

  • Kenji Hashimoto
  • Hiroshi Mayahara
  • Atsuo Takashima
  • Takako Eguchi Nakajima
  • Ken Kato
  • Tetsuya Hamaguchi
  • Yoshinori Ito
  • Yasuhide Yamada
  • Yoshikazu Kagami
  • Jun Itami
  • Yasuhiro Shimada
Original Paper

Abstract

Purpose

To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer.

Methods

Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2–50 Gy) and 2.5 Gy (range 1.8–3 Gy).

Results

The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy10 or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively.

Conclusion

Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.

Keywords

Gastric cancer Radiotherapy Bleeding Hemostasis 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Kenji Hashimoto
    • 1
  • Hiroshi Mayahara
    • 2
  • Atsuo Takashima
    • 1
  • Takako Eguchi Nakajima
    • 1
  • Ken Kato
    • 1
  • Tetsuya Hamaguchi
    • 1
  • Yoshinori Ito
    • 2
  • Yasuhide Yamada
    • 1
  • Yoshikazu Kagami
    • 2
  • Jun Itami
    • 2
  • Yasuhiro Shimada
    • 1
  1. 1.Gastrointestinal Oncology DivisionNational Cancer Center HospitalTokyoJapan
  2. 2.Radiation Oncology DivisionNational Cancer Center HospitalTokyoJapan

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