Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection

  • Yi-Wei Li
  • Shuang-Jian Qiu
  • Jia Fan
  • Qiang Gao
  • Jian Zhou
  • Yong-Sheng Xiao
  • Yang Xu
  • Xiao-Ying Wang
  • Jian Sun
  • Xiao-Wu Huang
Original Paper



To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (TM), in hepatocellular carcinoma (HCC) patients following resection.


The infiltration of TAM and TM was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/TM infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed.


High TAM infiltration was associated with both improved DFS (P = 0.0021) and OS (P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS (P = 0.004) and OS (P = 0.049). A second analysis clarified the synergistic effect of TAM&TM infiltration for DFS (P = 0.004) and OS (P = 0.040).


Both TAM infiltration alone and concomitant infiltration of TAM&TM are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms.


Tumor-associated macrophages (TAM) CD45RO + T cell (TMHepatocellular carcinoma (HCC) Prognosis 



Hepatocellular carcinoma


Tumor-associated macrophages


CD45RO + T cell




Transcatheter arterial chemoembolization


Overall survival


Disease-free survival



Supplementary material

432_2008_469_MOESM1_ESM.doc (82 kb)
Electronic supplementary material Appendix Table 5 and 6 (DOC 82 kb)


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Yi-Wei Li
    • 1
  • Shuang-Jian Qiu
    • 1
  • Jia Fan
    • 1
  • Qiang Gao
    • 1
  • Jian Zhou
    • 1
  • Yong-Sheng Xiao
    • 1
  • Yang Xu
    • 1
  • Xiao-Ying Wang
    • 1
  • Jian Sun
    • 1
  • Xiao-Wu Huang
    • 1
  1. 1.Liver Cancer Institute, Zhong Shan Hospital and Institutes of Biomedical Sciences, Shanghai Medical SchoolFudan UniversityShanghaiPeople’s Republic of China

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