Clinical efficacy of all-trans retinoic acid for treating adult T cell leukemia

  • Yasuhiro Maeda
  • Terufumi Yamaguchi
  • Yasuki Hijikata
  • Miyako Tanaka
  • Chikara Hirase
  • Shunsuke Takai
  • Yasuyoshi Morita
  • Tetsuaki Sano
  • Jun-ichi Miyatake
  • Yoichi Tatsumi
  • Akihisa Kanamaru
Original Paper

Abstract

Purpose

We previously reported that all-trans retinoic acid (ATRA) inhibited growth in human T-cell leukemia virus type I (HTLV-I)-positive T-cell lines and in fresh cells from patients with adult T cell leukemia (ATL). Here, we confirmed the clinical effects of ATRA in 20 patients with ATL.

Materials and methods

The 20 patients (n = 20) with a median age of 56 (range 35–73) years who were diagnosed with ATL received ATRA orally.

Results

The efficacy of treatment was as follows: no complete response (CR), a partial response (PR) in 40% of the patients, no change (NC) in 45% of the patients, and a progressive disease (PD) in 15% of the patients. In seven acute-type ATL patients, a PR was achieved in two (28.5%), NC was observed in two (28.5%), and a PD was observed in three (42.8%). In three lymphoma-type ATL patients, a PR (100%) was achieved. Among four chronic-type ATL patients, a PR was achieved in one (25%) and NC was observed in the remaining three (75%). In six smoldering-type ATL patients, a PR was achieved in two (33.3%) and NC was observed in four (66.6%). The major side effects were headache (n = 5), transient liver dysfunction (n = 2), hyperlipidemia (n = 2), and anorexia (n = 1).

Conclusion

These results indicated that ATRA might be a useful agent for the safe treatment of ATL.

Keywords

HTLV-I ATL ATRA Antitumor activity Apoptosis 

Notes

Acknowledgments

The authors thank Mrs. K. Furukawa and Mrs. K. Niki for their technical support and Ms. S. Nagayama and Ms. S. Yoshida for preparing the manuscript.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Yasuhiro Maeda
    • 1
  • Terufumi Yamaguchi
    • 1
  • Yasuki Hijikata
    • 1
  • Miyako Tanaka
    • 1
  • Chikara Hirase
    • 1
  • Shunsuke Takai
    • 1
  • Yasuyoshi Morita
    • 1
  • Tetsuaki Sano
    • 1
  • Jun-ichi Miyatake
    • 1
  • Yoichi Tatsumi
    • 1
  • Akihisa Kanamaru
    • 1
  1. 1.Division of Hematology, Department of Internal MedicineKinki University School of MedicineOsakaJapan

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